Treatment of female pattern hair loss with a combination of spironolactone and minoxidil

Carlijn Hoedemaker; Sylvia van Egmond; Rodney Sinclair

doi:10.1111/j.1440-0960.2007.00332.x

Treatment of female pattern hair loss with a combination of spironolactone and minoxidil

Australas J Dermatol. 2007 Feb;48(1):43-5. doi: 10.1111/j.1440-0960.2007.00332.x.

Authors

Carlijn Hoedemaker¹, Sylvia van Egmond, Rodney Sinclair

Affiliation

¹ Department of Dermatology, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia.

PMID: 17222303
DOI: 10.1111/j.1440-0960.2007.00332.x

Abstract

A 53-year-old woman with clinical evidence of female pattern hair loss and histological evidence of androgenetic alopecia was initially treated with the oral antiandrogen spironolactone 200 mg daily. Serial scalp photography documented hair regrowth at 12 months; however, the hair regrowth plateaued, and at 24 months there had been no further improvement in hair density. Twice daily therapy with topical minoxidil 5% solution was then introduced and further regrowth documented, confirming the additive effect of combination therapy.

Publication types

Case Reports

MeSH terms

Administration, Cutaneous
Administration, Oral
Alopecia / diagnosis*
Alopecia / drug therapy*
Alopecia / pathology
Drug Therapy, Combination
Female
Humans
Middle Aged
Mineralocorticoid Receptor Antagonists / administration & dosage
Mineralocorticoid Receptor Antagonists / therapeutic use*
Minoxidil / administration & dosage
Minoxidil / therapeutic use*
Spironolactone / administration & dosage
Spironolactone / therapeutic use*
Vasodilator Agents / administration & dosage
Vasodilator Agents / therapeutic use*

Substances

Mineralocorticoid Receptor Antagonists
Vasodilator Agents
Spironolactone
Minoxidil