The triptorelin's short-term regulating effect on AMH,FSH when it is used to patients with the low risk untreated trophoblastic tumor during they accepted chemotherapy treatment
Author(s): Gulijianati·maoleti, Miherinisha·maimaiti, Mayinuer·niyazi
Pages: 2644-2648
Year: 2017 Issue: 16
Journal: Journal of Modern Oncology
Keyword: initial treatment of low-risk gestational trophoblastic tumor; triptorelin; AMH; FSH;
Abstract: Objective:To study and evaluate on the trophoblastic''s short-term regulation on the AMH and FSH level of the patients with the low risk GTN during the chemotherapy.Methods:We collected the data from July 2012 to September 2015 in our hospital received chemotherapy for low-risk initial treatment in patients with trophoblastic tumor in 50 cases,the patients were divided into the observation group and control group according to whether to use the triptorelin,25 cases in each group.The curative efficacy of chemotherapy in the two groups was analyzed,including the effect of bone marrow suppression,gastrointestinal reaction and liver function.The serum levels of AMH and FSH were compared between the two groups at the end of chemotherapy and at the end of chemotherapy for the last 1 year.Results:The observation group after chemotherapy and 1 year after the end of the AMH levels were significantly higher than those in the control group(P<0.05).The level of AMH after 1 year after the end of chemotherapy group was significantly lower than that of the group before chemotherapy and after chemotherapy AMH level(P<0.05).The control group were significantly different(P<0.05) changes of AMH level,and the FSH level had the same trend.Conclusion:Triptorelin used in low risk of initial treatment in patients with trophoblastic tumor chemotherapy,no adverse effects on the effect of chemotherapy and ovarian reserve function and can protect the patients.
Pages: 2644-2648
Year: 2017 Issue: 16
Journal: Journal of Modern Oncology
Keyword: initial treatment of low-risk gestational trophoblastic tumor; triptorelin; AMH; FSH;
Abstract: Objective:To study and evaluate on the trophoblastic''s short-term regulation on the AMH and FSH level of the patients with the low risk GTN during the chemotherapy.Methods:We collected the data from July 2012 to September 2015 in our hospital received chemotherapy for low-risk initial treatment in patients with trophoblastic tumor in 50 cases,the patients were divided into the observation group and control group according to whether to use the triptorelin,25 cases in each group.The curative efficacy of chemotherapy in the two groups was analyzed,including the effect of bone marrow suppression,gastrointestinal reaction and liver function.The serum levels of AMH and FSH were compared between the two groups at the end of chemotherapy and at the end of chemotherapy for the last 1 year.Results:The observation group after chemotherapy and 1 year after the end of the AMH levels were significantly higher than those in the control group(P<0.05).The level of AMH after 1 year after the end of chemotherapy group was significantly lower than that of the group before chemotherapy and after chemotherapy AMH level(P<0.05).The control group were significantly different(P<0.05) changes of AMH level,and the FSH level had the same trend.Conclusion:Triptorelin used in low risk of initial treatment in patients with trophoblastic tumor chemotherapy,no adverse effects on the effect of chemotherapy and ovarian reserve function and can protect the patients.
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