Clinical Study of Oxycodone for Prventing Hyperalgesia After Remifentanil Intravenous Anesthesia
Author(s): Hu Chunhuan, Zhang Qi, Chai Fangyuan, Liu Shuyu
Pages: 32-34
Year: 2017 Issue: 14
Journal: China Pharmaceuticals
Keyword: oxycodone; rremifentanil; hyperalgesia; intravenous anesthesia;
Abstract: Objective To investigate the clinical effect of oxycodone for prventing postoperative hyperalgesia after remifentanil intravenous anesthesia. Methods Totally 68 patients treated with remifentanil intravenous anesthesia admitted to our hospital in 2016 were randomly divided into the two groups. During operation,the two groups were given Remifentanil intravenous infusion for maintenance anesthesia. 10 min before the end of the operation,patients in the control group and the observation group were given fentanyl and oxycodone for preventing postoperative hyperalgesia. The postoperative recovery,VAS score and adverse reactions were compared between the two groups. Results The spontaneous breathing recovery time,postoperative recovery time and laryngeal mask extraction time in the observa-tion group were significantly shorter than those in the control group( P < 0. 05),The VAS scores at laryngeal mask was removed and 30 min after it was removed in the observation group were significantly lower than those in the control group ( P < 0. 05),the inci-dence rate of adverse reactions in the observation group was 5. 88%,which was lower than 11. 76% in the control group,but the dif-ference was not significant( P > 0. 05). Conclusion The clinical effect of oxycodone for prventing postoperative hyperalgesia after remifentanil intravenous anesthesiais is good,with less adverse reactions,it is worthy of clinical promotion.
Pages: 32-34
Year: 2017 Issue: 14
Journal: China Pharmaceuticals
Keyword: oxycodone; rremifentanil; hyperalgesia; intravenous anesthesia;
Abstract: Objective To investigate the clinical effect of oxycodone for prventing postoperative hyperalgesia after remifentanil intravenous anesthesia. Methods Totally 68 patients treated with remifentanil intravenous anesthesia admitted to our hospital in 2016 were randomly divided into the two groups. During operation,the two groups were given Remifentanil intravenous infusion for maintenance anesthesia. 10 min before the end of the operation,patients in the control group and the observation group were given fentanyl and oxycodone for preventing postoperative hyperalgesia. The postoperative recovery,VAS score and adverse reactions were compared between the two groups. Results The spontaneous breathing recovery time,postoperative recovery time and laryngeal mask extraction time in the observa-tion group were significantly shorter than those in the control group( P < 0. 05),The VAS scores at laryngeal mask was removed and 30 min after it was removed in the observation group were significantly lower than those in the control group ( P < 0. 05),the inci-dence rate of adverse reactions in the observation group was 5. 88%,which was lower than 11. 76% in the control group,but the dif-ference was not significant( P > 0. 05). Conclusion The clinical effect of oxycodone for prventing postoperative hyperalgesia after remifentanil intravenous anesthesiais is good,with less adverse reactions,it is worthy of clinical promotion.
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