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Association analysis of the white matter hyperintensities and clinical characteristics and right-to-left shunt in migraine
Author(s): XIE Hui, ZHANG Qiang, JIAN Zhijie, BIAN Yitong, HUO Kang, LIU Rui, ZHU Dan, ZHANG Lihui, YANG Jian, LUO Guogang
Pages: 166-
170
Year: 2017
Issue:
3
Journal: Journal of Clinical Neurology
Keyword: migraine; white matter hyperintensities; right-to-left shunt;
Abstract: Objective To explore the risk factors of white matter hyperintensities (WMHs) in migraine patients from the perspectives of clinical characteristics and to investigate whether right-to-left shunt (RLS) relates to the WMHs.Methods Migraine patients were recruited to complete a questionnaire involving headache features, and underwent contrast-enhanced TCD for detecting the presence and grade of RLS and brain MRI scanning for WMHs evaluation.Results Fifty-seven migraine patients were enrolled.WMHs were detected in 18 cases(31.6%).The WMHs were mainly located in the frontal and parietal lobe and the lesions were generally mild.The differences of age, gender, headache features, scores of anxiety and depression and RLS between WMHs group and non-WMHs group were compared, and only age (P=0.002) and disease duration (P=0.046) showed significant differences.Conclusions WMHs in migraine are mainly located in frontal and parietal lobe.Age and disease duration may be the risk factors of the WMHs.The associations between the presence of WMHs and the presence of aura, attack frequency, headache duration, headache degree or anxiety and depression are not found.RLS is neither associated with the risk of WMHs in migraine.
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