Author(s): Zhang Yanshou, Tang Tiantian, Zhou Tao, Wang Xinle, Liu Yunjiang
Pages: 2588-2591
Year: 2017 Issue:  16
Journal: Journal of Modern Oncology
Keyword:  breast cancer; neoadjuvant chemotherapy;
Abstract: Objective:To investigate whether the expression of BCRP and Ki-67 expression in breast cancer could predict the efficacy of neoadjuvant chemotherapy.Methods:This research retrospectively analyzed 65 patients, who were diagnosed as invasive ductal carcinomas in stage Ⅱ-Ⅲ admitted in the breast cancer center in our hospital and accepted NAC from October 2012 to Augest 2014.Immunohistochemical assay was used to detect the BCRP and Ki-67 protein levels of 65 breast cancer tissues obtained by core needle biopsy before neoadjuvant chemotherapy.The relationship of BCRP and Ki-67 expression with efficacy of neoadjuvant chemotherapy was statistically analyzed.Results:The positive expression rate of BCRP was 67.7% in patients with primary breast cancer.The expression of BCRP was associated with the pathological response after neoadjuvant chemotherapy.BCRP expression in group of major histological response(grade of 4~5) was significantly lower than that in group of non major histological response(grade of 1~3)(x2=12.77,P=0.001).Patients with Ki-67 over-expression were more sensitive than those with lower-expression(x2=17.72,P<0.00).Conclusion:The protein levels of BCRP and Ki-67 showed predictive value of the efficacy of neoadjuvant chemotherapy.