Neoadjuvant Chemotherapy followed by Concurrent Chemoradiotherapy for the Prognosis of Locally Advanced Nasopharyngeal Carcinoma:A Meta-analysis
Author(s): Yang Jianquan, Guo Wen, Wen Shimin, Li Dezhi, Guo Cuihua, Zhang Xinping, Bie Jun, Hu xin, Li Guangming
Pages: 174-181
Year: 2017 Issue: 3
Journal: Journal of Cancer Control and Treatment
Keyword: Nasopharyngeal Carcinoma; Neoadjuvant Chemotherapy; Concurrent Chemoradiotherapy; Meta Analysis;
Abstract: Objective: To evaluate the survival of patients with locally advanced nasopharyngeal carcinoma treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy compared with concurrent chemoradiotherapy alone.Methods: Seven databases were searched,including the Cochrane Library(Issue 2,2016),Pubmed,Embase,CBM,CNKI,VIP and Wanfang Database.The methodological quality assessment of eligible researches was conducted according to the Jadad scale and The Newcastal-Ottawa Scale.The Meta-analysis was performed by the Revman 5.3 software.Results: Eleven researches containing 1 521 patients were finally included.The 5-year distant metastasis-free survival of patients treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy was significantly higher than that of those treated with concurrent chemoradiotherapy alone.There were no significant difference in 3-year overall survival,3-year distant metastasis-free survival,3-year progression-free survival,3-year recurrence free survival,5-year overall survival,5-year progression-free survival and 5-year recurrence free survival (P>0.05) respectively between these two regimens.Conclusion: Current evidence shows that compared with concurrent chemoradiotherapy alone,neoadjuvant chemotherapy followed by concurrent chemoradiotherapy could improve distant metastasis-free survival in locally advanced nasopharyngeal carcinoma,while no difference was found of the total survival between these two regimens.
Pages: 174-181
Year: 2017 Issue: 3
Journal: Journal of Cancer Control and Treatment
Keyword: Nasopharyngeal Carcinoma; Neoadjuvant Chemotherapy; Concurrent Chemoradiotherapy; Meta Analysis;
Abstract: Objective: To evaluate the survival of patients with locally advanced nasopharyngeal carcinoma treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy compared with concurrent chemoradiotherapy alone.Methods: Seven databases were searched,including the Cochrane Library(Issue 2,2016),Pubmed,Embase,CBM,CNKI,VIP and Wanfang Database.The methodological quality assessment of eligible researches was conducted according to the Jadad scale and The Newcastal-Ottawa Scale.The Meta-analysis was performed by the Revman 5.3 software.Results: Eleven researches containing 1 521 patients were finally included.The 5-year distant metastasis-free survival of patients treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy was significantly higher than that of those treated with concurrent chemoradiotherapy alone.There were no significant difference in 3-year overall survival,3-year distant metastasis-free survival,3-year progression-free survival,3-year recurrence free survival,5-year overall survival,5-year progression-free survival and 5-year recurrence free survival (P>0.05) respectively between these two regimens.Conclusion: Current evidence shows that compared with concurrent chemoradiotherapy alone,neoadjuvant chemotherapy followed by concurrent chemoradiotherapy could improve distant metastasis-free survival in locally advanced nasopharyngeal carcinoma,while no difference was found of the total survival between these two regimens.
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