The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit
later.
We apologize for any inconvenience caused
Effect of mifepristone on the prostaglandin and progesterone in patients with endometriosis dysmenorrhea
Author(s): ZHAO Lei, ZHANG Juanjuan, TIAN Xiaohua
Pages: 49-
51
Year: 2017
Issue:
7
Journal: The Chinese Journal of Human Sexuality
Keyword: Endometriosis; Dysmenorrheal; Mifepristone; Prostaglandin; Progesterone;
Abstract: Objectives:To study the effect of mifepristone on the prostaglandin and progesterone in patients with endometriosis dysmenorrhea.Methods:100 patients with endometriosis dysmenorrhea from January 2013 to January 2016 in our hospital were selected and divided randomly into observation group and control group,each of 50 cases.The control group were treated with danazol,while the observation group received Mifepristone Tablets on such basis.The treatment effect was compared.Results:After treatment,the prostaglandin F1α (PGF1α) and thromboxane B2 (TXB2) in observation group was lower than those in the control group [(37.98 ± 3.12)pg/ml vs(48.76 ± 4.02) pg/ml,(134.23 ± 27.54) pg/ml vs (156.78 ± 26.41) pg/ml] (P < 0.05);the follicle stimulating hormone (FSH),progesterone (LH),estradiol (E2) were better than those in the control group [(4.07 ±1.32)U/Lvs (7.45±1.74)U/L,(9.34±1.11)U/L vs (13.87 ±1.25)U/L,(784.31 ±40.91)pmol/L vs (573.56 ± 35.42)pmoL/L] (P < 0.05);dysmenorrhea VAS scores were significantly lower than that in the control group [(2.51 ±0.35) scores vs (4.78-± 0.33) scores] (P < 0.05);the total effective rate in the observation group was significantly higher than the control group [98.00% (48/50) vs 78.00% (39/40)] (P < 0.05).Conclusion:The use of mifepristone is effective in treating endometriosis dysmenorrhea patients,which can improve the level of prostaglandin and progesterone effectively and alleviate the symptoms of dysmenorrhea,thusly worthy of application and promotion.
Citations
No citation found
Related Articles
No related articles found