Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Counting the cost of lineage decisions

Nature Immunology volume 18, pages 872–873 (2017)Cite this article

Subjects

Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Defining the quantitative effect of lineage bias on blood-cell production.

References

  1. Lee, J. et al. Nat. Immunol. 18, 877–888 (2017).

    Article  CAS  Google Scholar 

  2. Notta, F. et al. Science 351, aab2116 (2016).

    Article  Google Scholar 

  3. Olsson, A. et al. Nature 537, 698–702 (2016).

    Article  CAS  Google Scholar 

  4. Paul, F. et al. Cell 163, 1663–1677 (2015).

    Article  CAS  Google Scholar 

  5. Velten, L. et al. Nat. Cell Biol. 19, 271–281 (2017).

    Article  CAS  Google Scholar 

  6. Akashi, K., Traver, D., Miyamoto, T. & Weissman, I.L. Nature 404, 193–197 (2000).

    Article  CAS  Google Scholar 

  7. Manz, M.G., Miyamoto, T., Akashi, K. & Weissman, I.L. Proc. Natl. Acad. Sci. USA 99, 11872–11877 (2002).

    Article  CAS  Google Scholar 

  8. Pronk, C.J. et al. Cell Stem Cell 1, 428–442 (2007).

    Article  CAS  Google Scholar 

  9. Yáñez, A., Ng, M.Y., Hassanzadeh-Kiabi, N. & Goodridge, H.S. Blood 125, 1452–1459 (2015).

    Article  Google Scholar 

  10. Naik, S.H. et al. Nature 496, 229–232 (2013).

    Article  CAS  Google Scholar 

  11. Murphy, T.L. et al. Annu. Rev. Immunol. 34, 93–119 (2016).

    Article  CAS  Google Scholar 

  12. Kueh, H.Y., Champhekar, A., Nutt, S.L., Elowitz, M.B. & Rothenberg, E.V. Science 341, 670–673 (2013).

    Article  CAS  Google Scholar 

  13. Hoppe, P.S. et al. Nature 535, 299–302 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Board of Governors Regenerative Medicine Institute and the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Alberto Yáñez & Helen S Goodridge

  2. Division of Immunobiology and Center for Systems Immunology and the Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

    H Leighton Grimes

Authors
  1. Alberto Yáñez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Helen S Goodridge
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H Leighton Grimes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to H Leighton Grimes.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yáñez, A., Goodridge, H. & Grimes, H. Counting the cost of lineage decisions. Nat Immunol 18, 872–873 (2017). https://doi.org/10.1038/ni.3794

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3794

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing