Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation
DOI: 10.1039/C7CC04291D, Communication
Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon…
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