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plunc dan bai zai kou qiang ji bing zhong de yan jiu jin zhan
Author(s): CHEN Qiaoyun
Pages: 436-
438
Year: 2017
Issue:
7
Journal: Journal of Clinical Stomatology
Keyword: PLUNC; 天然免疫分子; 牙周炎; 唾液腺肿瘤;
Abstract: 腭、肺及鼻咽上皮克隆(palate,lung and nasal epithelium clone,PLUNC)家族是新近发现的天然免疫分子,特异性的表达于上呼吸道、口腔及消化道,可通过杀菌/细菌渗透增强蛋白结构域(bactericidal permeability increasing protein,BPI)与细菌脂多糖结合,抑制或杀灭革兰氏阴性菌.最新的研究表明PLUNC蛋白与牙周炎、口腔扁平苔藓等口腔炎症性疾病相关,在固有免疫防御中发挥抗炎抑菌作用,并可能成为某些唾液腺肿瘤的标记分子.本文将就PLUNC在口腔疾病中的研究进展作一综述.
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