Progress on Long Non-coding RNA in Cancer Research
Author(s): WEI Mei-rong, WEN Li-fen, LI Yu
Pages: 535-540
Year: 2017 Issue: 6
Journal: Journal of Oncology
Keyword: lncRNA; tumor; biomarker;
Abstract: Longnon coding RNAs(lncRNAs)are defined as transcripts longer than 200 nt with little or no proteincoding capacity that are generally transcribed in the mammalian genome.Initially,they are considered to be a byproduct in the transcription process without biological function.As investigations have progressed,new lncRNAs have been constantly found.And lncRNAs have been found to affect species evolution,embryonic development,metabolism and tumorigenesis.Recent studies suggest that LncRNAs tissue specially expressed in several human cancers,and might play a key role in the diagnosis and prognostic of these malignant neoplasms.This review summarizes the relationship between IncRNA and the occurrence and development of malignancies.
Pages: 535-540
Year: 2017 Issue: 6
Journal: Journal of Oncology
Keyword: lncRNA; tumor; biomarker;
Abstract: Longnon coding RNAs(lncRNAs)are defined as transcripts longer than 200 nt with little or no proteincoding capacity that are generally transcribed in the mammalian genome.Initially,they are considered to be a byproduct in the transcription process without biological function.As investigations have progressed,new lncRNAs have been constantly found.And lncRNAs have been found to affect species evolution,embryonic development,metabolism and tumorigenesis.Recent studies suggest that LncRNAs tissue specially expressed in several human cancers,and might play a key role in the diagnosis and prognostic of these malignant neoplasms.This review summarizes the relationship between IncRNA and the occurrence and development of malignancies.
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