Combination of Magnetic Resonance Spectroscopy and 11C-methionine PET in Early Diagnosis of Non-enhancing Supratentorial Glioma
Author(s): Nijiati Kudulaiti, YAO Cheng-jun, QIU Tian-ming, LU Jun-feng, ZHANG Hui-wei, ZHANG Zheng-wei, WANG Yang, ZHANG Dong-xiao, GUAN Yi-hui, WU Jin-song
Pages: 252-258
Year: 2017 Issue: 3
Journal: Chinese Journal of Clinical Neurosciences
Keyword: glioma; magnetic resonance spectroscopy; methionine; positron emission tomography;
Abstract: Aim To investigate whether the combination of magnetic resonance spectroscopy (MRS) and11C-methionine positron emission tomography (11C-MET PET) can increase the true positive rate of early diagnosis of non-enhancing supratentorial gliomas.Methods 65 patients with non-enhancing supratentorial lesions which were confirmed to be gliomas by surgery were enrolled in this study. Each patient underwent both MRS imaging and11C-MET PET scan prior to surgery. The lesion was considered as a glioma when either MRS or11C-MET PET results indicated the diagnosis [maximum Cho/NAA index (CNImax) higher than 2.0 in MRS or tumor versus normal tissue ratio (T/N ratio) higher than 1.3 in 11C-MET PET]. The results of metabolic evaluation were compared with the pathologic diagnosis.Results The true positive rate of MRS imaging was 60.0%, the true positive rate of11C-MET PET was 78.5%. When combining the two examinations, 89.2% of patients were presumed to have gliomas by imaging diagnosis prior to surgery. The difference between the combination of the two examinations and the single examination was statistically signiifcant (P<0.05).Conclusion The combination of MRS and11C-MET PET can significantly elevate the true positive rate of early diagnosis of non-enhancing supratentorial gliomas, which is suitable and promising in clinical applications.
Pages: 252-258
Year: 2017 Issue: 3
Journal: Chinese Journal of Clinical Neurosciences
Keyword: glioma; magnetic resonance spectroscopy; methionine; positron emission tomography;
Abstract: Aim To investigate whether the combination of magnetic resonance spectroscopy (MRS) and11C-methionine positron emission tomography (11C-MET PET) can increase the true positive rate of early diagnosis of non-enhancing supratentorial gliomas.Methods 65 patients with non-enhancing supratentorial lesions which were confirmed to be gliomas by surgery were enrolled in this study. Each patient underwent both MRS imaging and11C-MET PET scan prior to surgery. The lesion was considered as a glioma when either MRS or11C-MET PET results indicated the diagnosis [maximum Cho/NAA index (CNImax) higher than 2.0 in MRS or tumor versus normal tissue ratio (T/N ratio) higher than 1.3 in 11C-MET PET]. The results of metabolic evaluation were compared with the pathologic diagnosis.Results The true positive rate of MRS imaging was 60.0%, the true positive rate of11C-MET PET was 78.5%. When combining the two examinations, 89.2% of patients were presumed to have gliomas by imaging diagnosis prior to surgery. The difference between the combination of the two examinations and the single examination was statistically signiifcant (P<0.05).Conclusion The combination of MRS and11C-MET PET can significantly elevate the true positive rate of early diagnosis of non-enhancing supratentorial gliomas, which is suitable and promising in clinical applications.
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