Author(s): LIU Fuzhi, LI Hongtu, WU Chuancheng, CAI Ailan, CHEN Yu, LIU Baoying
Pages: 230-234
Year: 2017 Issue:  3
Journal: Carcinogenesis,Teratogenesis and Mutagenesis
Keyword:  chemical element; gastric cancer; case control; plasma;
Abstract: OBJECTIVE: To compare the presence of chemical elements in plasma between gastric cancer patients and healthy people. METHODS:Using a case-control design,we focused on people who had lived in Xianyou for 10 years or more. Among them,we identified newly discovered cases of pathologically confirmed gastric cancer (299 cases) and 295 health cases. Among these cases,we obtained general situation information,living habits,etc. using questionnaires and collected blood samples. Blood samples were subjected to microwave digestion and chemical elements in plasma were analyzed by inductively coupled plasma mass spectrometry. The presence of chemical elements between the two groups were compared using non-parametric tests. RESULTS:Cu,Mg,and Cu/Zn in the case group were significantly higher than that in the control (P<0.01). However,Mo,Ca in the case group were significantly lower (P<0.01). Multivariate analysis showed that Cu (OR=2.71),Mg (OR=2.26),Cu/Zn (OR=3.88) were significantly associated with increased risk for gastric cancer but Mo (OR=0.48),Ca (OR=0.17) with significantly reduced risk. CONCLUSION:Levels of some plasma chemical elements in gastric cancer patients were significantly different from that of the normal population.