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Prevalence of human papilloma-virus genotypes and associated risk of cervical carcinoma in Chaoshan population
Author(s): SHEN Ling, XU Lixuan, LI Xiaoping, HU Guiying, MAI Bi, JI Xuan, LI Li
Pages: 226-
229
Year: 2017
Issue:
3
Journal: Carcinogenesis,Teratogenesis and Mutagenesis
Keyword: Chaoshan area; human papillomavirus; genotype; cervical carcinoma;
Abstract: OBJECTIVE: To determine genotype-specific distribution of human papillomavirus (HPV) in women and to identify its relationship with cervical carcinoma in Chaoshan population. METHODS:Data from 30000 women who were subjected to cervical HPV DNA testing were retrospectively evaluated in a hospital-based study. A total of 8739 women,who had both HPV typing and pathological examination,were investigated. RESULTS:Overall,30.00%(9000/30000) of women were HPV positive,the frequency of HPV infection was 58.29% (5094/8739) in women with cervical cytological abnormalities,and the infection rate for patients with chronic cervicitis was 40.00% (1088/2720),patients with CIN I was 53.59%(1396/2605),patients with CIN was Ⅱ/Ⅲ 71.61% (1647/2300) and patients with cervical carcinoma was 86.45%(963/1114). HPV 16 (14.02%) was the most common type for all cervical cytological abnormalities,followed by 18 type 6.28%(549),33 type 5.23%(457),58 type 4.46%(390) and 52 type 3.71%(324),while the more common HPV 16 type in cervical carcinoma with the highest infection (49.92%) was in women aged over 60. CONCLUSION:Our data indicate a relatively high prevalence of HPV 16,52,33,58 and 18 in women,their positive association with cervical cytological abnormalities. Specifically,the HPV 16 was the most common subtype among senior women with cervical carcinoma.
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