Author(s): Tong Hui, Lin Fujun, Jiang Aizhong, Zhou Chang, Hu Tingting
Pages: 18-21
Year: 2017 Issue:  11
Journal: Chinese Journal of Practical Nervous Diseases
Keyword:  Leukoaraiosis; Aspirin; Cerebral hemorrhage;
Abstract: Objective To investigate the effect of aspirin on the prevention of stroke in patients with periventricular leukoaraiosis.Methods Four hundred lacunar infarction patients with periventricular leukoaraiosis were randomly divided into the treatment group (200 cases,aspirin) and the control group.The cases in the treatment group received aspirin 100 mg daily for 1 year,and patients in control group didn't take antiplatelet or anticoagulant drugs.All cerebrovascular events occurred in patients prescribed in one year.In all participants we measured the score of the Montreal Cognitive Assessment,the severity of periventricular leukoaraiosis and the number of cerebral microbleeds at the begining and the ending of this trial.Results The numbers of cerebral microbleeds in the treatment group were significantly higher than those in the control group.The incidence of acute cerebral infarction in the treatment group was significantly lower than that in the control group.There were no significant differences in the the incidence of acute cerebral hemorrhage,the score of the Montreal Cognitive Assessment and the severity of periventricular leukoaraiosis between two groups.Conclusion Among lacunar infarction patients with periventricular leukoaraiosis,aspirin can reduce the risk of acute cerebral infarction and has no side effect.