Retrospective analysis of aprepitant combined with tropisetron in the treatment of nausea and vomiting induced by chemotherapy
Author(s): DING Hong, SHI Weiwei, WANG Zhikuan, DAI Guanghai
Pages: 408-410,431
Year: 2017 Issue: 4
Journal: Oncology Progress
Keyword: aprepitant; tropisetron; chemotherapy; moderate/severe nausea and vomiting; clinical efficacy;
Abstract: Objective To analyze the clinical efficacy of aprepitant combined with tropisetron in the treatment of nau-sea and vomiting induced by chemotherapy and drug-related adverse reactions (ADR). Method Patients with partial re-sponse or nonresponsive to tropisetron antemetic monotherapy were enrolled in the study, and then were administered with tropisetron monotherapy (n=107) or aprepitant combined with tropisetron (n=106), respectively, the antiemetic effect and adverse reactions in the two groups were analyzed. Result Among 213 evaluable patients, the control rates of acute nausea and vomiting by tropisetron or aprepitant+tropisetron were 13.1%and 95.3%respectively (P<0.01), the control rates of delayed nausea and vomiting were 37.4%and 96.2%(P<0.01). The most common ADR of both regimens were hiccups, constipation, headache, dizziness, dry mouth, anxiety, etc., with no statistical significance observed for the inci-dence of ADR (P>0.05). Conclusion The aprepitant combined with tropisetron regimen is effective for moderate/severe nausea and vomiting induced by chemotherapy with tolerable toxicity profile.
Pages: 408-410,431
Year: 2017 Issue: 4
Journal: Oncology Progress
Keyword: aprepitant; tropisetron; chemotherapy; moderate/severe nausea and vomiting; clinical efficacy;
Abstract: Objective To analyze the clinical efficacy of aprepitant combined with tropisetron in the treatment of nau-sea and vomiting induced by chemotherapy and drug-related adverse reactions (ADR). Method Patients with partial re-sponse or nonresponsive to tropisetron antemetic monotherapy were enrolled in the study, and then were administered with tropisetron monotherapy (n=107) or aprepitant combined with tropisetron (n=106), respectively, the antiemetic effect and adverse reactions in the two groups were analyzed. Result Among 213 evaluable patients, the control rates of acute nausea and vomiting by tropisetron or aprepitant+tropisetron were 13.1%and 95.3%respectively (P<0.01), the control rates of delayed nausea and vomiting were 37.4%and 96.2%(P<0.01). The most common ADR of both regimens were hiccups, constipation, headache, dizziness, dry mouth, anxiety, etc., with no statistical significance observed for the inci-dence of ADR (P>0.05). Conclusion The aprepitant combined with tropisetron regimen is effective for moderate/severe nausea and vomiting induced by chemotherapy with tolerable toxicity profile.
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