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Cognitive function characteristics of the remitted major depressive disorder: a prospective study
Author(s): DONG Qiangli, WAN Ping, SUN Jinrong, LU Xiaowen, GUO Hua, GUO Zhenyu, ZHAO Futao, ZUO Qin, LI Zhigang, ZHANG Shuai, ZHANG Liang, LI Weizuo, LI Zexuan, ZHANG Yan, ZHANG Li, LIAO Mei, WANG Zuo, WANG Dandan, LIU Bangshan, LIU Tiebang, LI Lingjiang
Pages: 182-
186
Year: 2017
Issue:
3
Journal: Chinese Journal of Psychiatry
Keyword: Depressive disorder; Cognitive function; State type; Endophenotype;
Abstract: Objective To explore the cognitive function characteristics in major depressive disorder (MDD) before and after 6-month treatment. Methods Assessed the severity of depression with 24-Item Hamilton Depression Rating Scale (HAMD24), 103 MDD were matched with 104 healthy controls (HCs). Both groups of the subjects were measured cognitive function with WSCT and neurocognitive assessments package, including the Stroop Color Word Test, the Trail Making Test, the Verbal Fluency Test and the Wechsler Memory Scale, before and after 6 months of paroxetine treatment. ANOVA and simple effect analysis were used to compare the differences in cognitive factors between the groups. Results At baseline, the verbal fluency, processing speed, cognitive flexibility,learning and memory in MDD patients were significantly worse than that in the HCs(t=-7.441--4.601,P<0.01). Analyzed by a two-way repeated measures ANOVA, the verbal fluency in remitted MDD(n=53)was still significantly worse than follow-up HCs(n=31;-0.38±0.87 vs. 0.08±0.94;F=7.672,P=0.007), however there were no significant interaction of group×time (F=0.625,P=0.432), or any significant difference between two groups at different time (F=1.484, P=0.227). While all other cognitive factors had significant interactions of group × time(P<0.05 or P<0.01). Analyzed by the simple effect analysis, all other cognitive factors were significantly worse in MDD at baseline (P<0.05 or P<0.01)but no significant difference between two groups at the end of the six-month follow-up. Conclusion MDD exhibits impairment in cognitive function before effective treatment. The verbal fluency may serve as potential cognitive endophenotypes that will not be changed after the treatment, while the other cognitive factors may serve as state types which are possibly able to restore after the treatment.
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