Effect of 8-week escitalopram monotherapy on posterior cingulate functional connectivity in patients with major depressive disorder
Author(s): Cheng Yuqi, Yu Hongjun, Lu Jin, Liu Fang, Luo Chunrong, Wang Jicai, Xu Xiufeng
Pages: 201-207
Year: 2017 Issue: 3
Journal: Chinese Journal of Psychiatry
Keyword: Depressive disorder; Antidepressive agents; Magnetic resonance imaging; Posterior cingulate; Resting state; Functional connectivity;
Abstract: Objective This study aimed to find the resting state functional connectivity of posterior cingulate with other brain regions in major depressive disorder(MDD), as well as the effect and correlations with antidepressant agents. Methods Twenty-one first-episode MDD patients according to the diagnosis criteria of DSM-Ⅳ and 21 sex-, age-, and education-matched health controls were recruited. All subjects underwent brain resting state fMRI scans at baseline. Depressive patients subsequently underwent 8 weeks of escitalopram monotherapy, and took resting state fMRI at the end of the treatment. The left posterior cingulate gyrus was selected as the region of interest, and the time series of the extraction of the posterior cingulate and the whole brain were analyzed. Results Compared to controls,MDD patients showed abnormal brain functional connectivity at baseline, especially increased functional connectivity in the hippocampus and parahippocampal gyrus(Z=4.70), left middle frontal(Z=4.65,both P<0.05), but decreased functional connectivity in the right middle frontal gyrus(Z=3.98), right temporal pole(Z=3.66), bilateral inferior temporal gyrus(Z=3.80), bilateral occipital gyrus(Z=3.57,3.54;all P<0.05). The drug significantly increased the functional connectivity of posterior cingulate with right inferior frontal gyrus(Z=4.35), right precentral gyrus(Z=5.87), left middle temporal gyrus(Z=3.96), left middle occipital gyrus(Z=3.65)and insula cortex, while reduced the functional connectivity of posterior cingulate with the bilateral superior frontal gyrus(Z=5.10), bilateral precuneus(Z=5.63), right hippocampus and parahippocampal gyrus(Z=4.96), right angular gyrus(Z=3.65, all P<0.05). Conclusion There may be abnormal resting state functional connectivities of the posterior cingulate with other brain regions in MDD patients, these abnormalities could partially change after escitalopram treatment, suggesting these abnormal connectivities might be correlated with the clinical efficacy.
Pages: 201-207
Year: 2017 Issue: 3
Journal: Chinese Journal of Psychiatry
Keyword: Depressive disorder; Antidepressive agents; Magnetic resonance imaging; Posterior cingulate; Resting state; Functional connectivity;
Abstract: Objective This study aimed to find the resting state functional connectivity of posterior cingulate with other brain regions in major depressive disorder(MDD), as well as the effect and correlations with antidepressant agents. Methods Twenty-one first-episode MDD patients according to the diagnosis criteria of DSM-Ⅳ and 21 sex-, age-, and education-matched health controls were recruited. All subjects underwent brain resting state fMRI scans at baseline. Depressive patients subsequently underwent 8 weeks of escitalopram monotherapy, and took resting state fMRI at the end of the treatment. The left posterior cingulate gyrus was selected as the region of interest, and the time series of the extraction of the posterior cingulate and the whole brain were analyzed. Results Compared to controls,MDD patients showed abnormal brain functional connectivity at baseline, especially increased functional connectivity in the hippocampus and parahippocampal gyrus(Z=4.70), left middle frontal(Z=4.65,both P<0.05), but decreased functional connectivity in the right middle frontal gyrus(Z=3.98), right temporal pole(Z=3.66), bilateral inferior temporal gyrus(Z=3.80), bilateral occipital gyrus(Z=3.57,3.54;all P<0.05). The drug significantly increased the functional connectivity of posterior cingulate with right inferior frontal gyrus(Z=4.35), right precentral gyrus(Z=5.87), left middle temporal gyrus(Z=3.96), left middle occipital gyrus(Z=3.65)and insula cortex, while reduced the functional connectivity of posterior cingulate with the bilateral superior frontal gyrus(Z=5.10), bilateral precuneus(Z=5.63), right hippocampus and parahippocampal gyrus(Z=4.96), right angular gyrus(Z=3.65, all P<0.05). Conclusion There may be abnormal resting state functional connectivities of the posterior cingulate with other brain regions in MDD patients, these abnormalities could partially change after escitalopram treatment, suggesting these abnormal connectivities might be correlated with the clinical efficacy.
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