Expression of the αvβ6 integrin is upregulated in several solid tumors. In contrast,
physiologic expression of this epithelial-specific integrin is restricted to development and …

Immunotherapy of cancer using chimeric antigen receptor (CAR) T-cells is a rapidly
expanding field. CARs are fusion molecules that couple the binding of a tumour-associated …

Integrins are heterodimeric receptors that convey cell‐to‐cell and cell‐to‐matrix interactions.
Integrin αvβ3 is expressed in several tumor entities including melanoma, glioblastoma …

Cholangiocarcinoma (CCA) is a lethal bile duct cancer that responds poorly to current
standard treatments. A new therapeutic approach is, therefore, urgently needed. Adoptive T …

Summary αvβ8 integrin, a key activator of transforming growth factor β (TGF-β), inhibits anti-
tumor immunity. We show that a potent blocking monoclonal antibody against αvβ8 (ADWA …

Background Diffuse intrinsic pontine glioma (DIPG) and glioblastoma (GBM) are two highly
aggressive and generally incurable gliomas with little therapeutic advancements made in …

ABSTRACT A key impediment to successful cancer therapy with adenoviral vectors is the
inefficient transduction of malignant tissue in vivo. Compounding this problem is the lack of …

Anti‐angiogenesis is a promising strategy for the treatment of cancer. Integrins, consisting of
two noncovalently bound transmembrane α and β subunits, are an important molecular …

Abstract αvβ6 integrin expression is upregulated on a wide range of epithelial tumours, and
is thought to play a role in modulating tumour growth. Here we describe a human …

Gamma delta T (γδT) lymphocytes are primed for rapid function, including cytotoxicity toward
cancer cells, and are a component of the immediate stress response. Following activation …