Correlation of reversely increased level of plasma glucose during pregnancy to the pregnancy outcome
Author(s): SHEN Xiao-ya, PAN Shi-lei, CAI Wei, ZHU Bao-ping, Department of Gynaecolog y and Obstetrics, Zhujiang Hospital of Southern Medical University
Pages: 47-51
Year: 2017 Issue: 1
Journal: Medical Journal of Chinese People's Liberation Army
Keyword: 75g oral glucose tolerance test; glucose metabolism disorders; pregnancy outcome;
Abstract: Objective To explore the correlation of the reversely increased results of 75 g oral glucose tolerance test(OGTT) during pregnancy to the pregnancy outcome, so as to provide a reliable theoretical basis of the early intervention for the pregnant women with high plasma glucose. Methods The clinical data of 461 cases were retrospectively analyzed. Patients were chosen from the pregnant women undergoing routine antenatal examination in our hospital during 2014. According to the results of 75 g OGTT, 226 patients were analyzed as the observation group, in whom the level of postprandial 2-hour plasma glucose was higher than that of postprandial 1-hour plasma glucose. Meanwhile 235 pregnant women with or without gestational diabetes mellitus(GDM) were randomly selected as the control group. Results The levels of fasting plasma glucose and 1-hour postprandial plasma glucose were lower, but those of 2-hour postprandial plasma glucose was higher in observation group than in control group(P<0.01). No statistical difference existed between the two groups(P>0.05) in the incidences of polyhydramnios, oligohydramnios, fetal growth restriction(FGR), premature labor(PTL), pregnancy induced hypertension(PIH), complicated with premature rupture of membrane(PROM), intrauterine fetal death(IUFD) and non scar uterus cesarean section rate(CSR). Compared with the observation group, the rates of neonatal dysplasia and neonatal asphyxia and the newborn transfer rate were lower in the control group, of which the newborn transfer rate was statistically different(P<0.01). Conclusions There might be a delayed plasma glucose metabolism in the patients with reversely increased result of 75 g OGTT during pregnancy, which may affect the long-term prognosis of the newborn. Therefore, more attention should be paid to such patients with reversely increased result of 75 g OGTT.
Pages: 47-51
Year: 2017 Issue: 1
Journal: Medical Journal of Chinese People's Liberation Army
Keyword: 75g oral glucose tolerance test; glucose metabolism disorders; pregnancy outcome;
Abstract: Objective To explore the correlation of the reversely increased results of 75 g oral glucose tolerance test(OGTT) during pregnancy to the pregnancy outcome, so as to provide a reliable theoretical basis of the early intervention for the pregnant women with high plasma glucose. Methods The clinical data of 461 cases were retrospectively analyzed. Patients were chosen from the pregnant women undergoing routine antenatal examination in our hospital during 2014. According to the results of 75 g OGTT, 226 patients were analyzed as the observation group, in whom the level of postprandial 2-hour plasma glucose was higher than that of postprandial 1-hour plasma glucose. Meanwhile 235 pregnant women with or without gestational diabetes mellitus(GDM) were randomly selected as the control group. Results The levels of fasting plasma glucose and 1-hour postprandial plasma glucose were lower, but those of 2-hour postprandial plasma glucose was higher in observation group than in control group(P<0.01). No statistical difference existed between the two groups(P>0.05) in the incidences of polyhydramnios, oligohydramnios, fetal growth restriction(FGR), premature labor(PTL), pregnancy induced hypertension(PIH), complicated with premature rupture of membrane(PROM), intrauterine fetal death(IUFD) and non scar uterus cesarean section rate(CSR). Compared with the observation group, the rates of neonatal dysplasia and neonatal asphyxia and the newborn transfer rate were lower in the control group, of which the newborn transfer rate was statistically different(P<0.01). Conclusions There might be a delayed plasma glucose metabolism in the patients with reversely increased result of 75 g OGTT during pregnancy, which may affect the long-term prognosis of the newborn. Therefore, more attention should be paid to such patients with reversely increased result of 75 g OGTT.
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