Analysis of Drug Resistance of 415 Pseudomonas aeruginosa Strains Isolated from Positive Samples in Blood Culture
Author(s): Guo Xia, Xu Yun-min, Shan Bin, Duan Yong, Department of Clinical Laboratory, The First Hospital Affiliated to Kunming Medical University
Pages: 9-13
Year: 2017 Issue: 1
Journal: China Licensed Pharmacist
Keyword: Blood Culture; Blood Infection; Pseudomonas Aeruginosa; Drug Resistance;
Abstract: Objective:To investigate the drug resistance of Pseudomonas aeruginosa isolated from the blood samples in tertiary hospitals in Yunnan province during 2013-2015 and provide a basis for the rational use of antibacterial drugs for clinical treatment of P. aeruginosa infection. Methods:The P. aeruginosa isolated from the blood samples in tertiary hosptials in Yunnan province from January 2013 to December 2015 were analyzed for resistance to antibacterial drugs by Whonet 5.6 software. The resistance rates of P. aeruginosa strains from blood and sputum samples were compared by SPSS 18.0 software. Results:A total of 415 P. aeruginosa strains were isolated from blood samples, including 115 in 2013, 143 in 2014 and 157 in 2015, which showed the highest resistance rate of 31.4% to aztreonam and the lowest resistance rate of 15.2% to amikacin. However, the resistance rate to piperacillin-tazobactam as a frist line antimicrobial agent was 22.7%. Apart from those to meropenem and tobramycin, the resistance rate of P. aeruginosa to other antimicrobial agents showed increasing tendencies. The resistance rates of P. aeruginosa strains from blood samples to piperacillin, cefepime, meropenem, gentamicin and amikacin were significantly higher than those from sputum samples(P < 0.05). The resistance rates of strains from children origin to most of antibacterial agents were lower than those from adult and the elderly orgins. Conclusion:The number of P. aeruginosa strains isolated from blood samples in tertiary hospitals of Yunnan province as well as the resistance rate to most routine antimicrobial agents including piperacillintazobactam increased year by year, while the resistance rate to several antibacterial agents were higher than those isolated from sputum samples. The monitoring on the drug-resistence of P. aeruginosa in blood samples should be strengthened so as to guide the rational drug use in clinic.
Pages: 9-13
Year: 2017 Issue: 1
Journal: China Licensed Pharmacist
Keyword: Blood Culture; Blood Infection; Pseudomonas Aeruginosa; Drug Resistance;
Abstract: Objective:To investigate the drug resistance of Pseudomonas aeruginosa isolated from the blood samples in tertiary hospitals in Yunnan province during 2013-2015 and provide a basis for the rational use of antibacterial drugs for clinical treatment of P. aeruginosa infection. Methods:The P. aeruginosa isolated from the blood samples in tertiary hosptials in Yunnan province from January 2013 to December 2015 were analyzed for resistance to antibacterial drugs by Whonet 5.6 software. The resistance rates of P. aeruginosa strains from blood and sputum samples were compared by SPSS 18.0 software. Results:A total of 415 P. aeruginosa strains were isolated from blood samples, including 115 in 2013, 143 in 2014 and 157 in 2015, which showed the highest resistance rate of 31.4% to aztreonam and the lowest resistance rate of 15.2% to amikacin. However, the resistance rate to piperacillin-tazobactam as a frist line antimicrobial agent was 22.7%. Apart from those to meropenem and tobramycin, the resistance rate of P. aeruginosa to other antimicrobial agents showed increasing tendencies. The resistance rates of P. aeruginosa strains from blood samples to piperacillin, cefepime, meropenem, gentamicin and amikacin were significantly higher than those from sputum samples(P < 0.05). The resistance rates of strains from children origin to most of antibacterial agents were lower than those from adult and the elderly orgins. Conclusion:The number of P. aeruginosa strains isolated from blood samples in tertiary hospitals of Yunnan province as well as the resistance rate to most routine antimicrobial agents including piperacillintazobactam increased year by year, while the resistance rate to several antibacterial agents were higher than those isolated from sputum samples. The monitoring on the drug-resistence of P. aeruginosa in blood samples should be strengthened so as to guide the rational drug use in clinic.
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