The prognostic role of TGF-β1 and PLGF in hydatidiform mole
Author(s): ZHANG Susu, LI Hongmei, LI Hongxia, YANG Chuan, GONG Haiye, GAO Le
Pages: 443-446
Year: 2017 Issue: 4
Journal: Oncology Progress
Keyword: transforming growth factorβ1; placental growth factor; hydatidiform mole;
Abstract: Objective To explore the expressions of transforming growth factor beta 1 (TGF-β1) and placental growth factor (PLGF) in hydatidiform mole. Method A total of 180 cases of hydatidiform mole were followed for at least 1 year, in which 30 cases developed invasive hydatidiform mole, and 1 was choriocarcinoma. Immunohistochemical method was used to detect the expression levels of TGF-β1 and PLGF in 33 cases with early abortion (control group), 33 cases with non-malignant hydatidiform mole (benign lesions group), and 31 cases with invasive hydatidiform mole (ma-lignant lesions group). Result The positive expression rates of TGF-β1 in invasive hydatidiform mole and choriocarcino-ma (58.1%) were significantly lower than that in benign lesions group (87.9%) and control group (97.0%) (P<0.05), while were similar between benign lesions and controls (P>0.05). As for PLGF, the patients with invasive hydatidiform mole and choriocarcinoma had higher positive expression rate (90.3%) than that in control group (36.4%) and benign lesions group (63.6%) (P<0.05), and it was comparable between benign lesions group and control group (P>0.05). Patients with age>40 years, hCG>105 U/L, and increased uterine volume had lower TGF-β1 expression (P<0.05) in benign and malig-nant lesions group;patients with theca lutein cyst diameter>6 cm or recurrent hydatidiform mole had similar positive ex-pression compared with those without the risk factors stated above (P>0.05). In benign and malignant lesions group, pa-tients with age>40 years, hCG>105 U/L, and increased uterine volume, or theca lutein cyst diameter>6 cm had higher PLGF expression rate than those without (P<0.05);and those with or without recurrent hydatidiform mole had consistent PLGF levels (P>0.05). There was a negative correlation between TGF-β1 and PLGF expression in patients benign and malignant lesions (P<0.05). Conclusion TGF-β1 and PLGF may become a new index of predicting malignant transfor-mation of hydatidiform mole which provides a basis for preventive chemotherapy.
Pages: 443-446
Year: 2017 Issue: 4
Journal: Oncology Progress
Keyword: transforming growth factorβ1; placental growth factor; hydatidiform mole;
Abstract: Objective To explore the expressions of transforming growth factor beta 1 (TGF-β1) and placental growth factor (PLGF) in hydatidiform mole. Method A total of 180 cases of hydatidiform mole were followed for at least 1 year, in which 30 cases developed invasive hydatidiform mole, and 1 was choriocarcinoma. Immunohistochemical method was used to detect the expression levels of TGF-β1 and PLGF in 33 cases with early abortion (control group), 33 cases with non-malignant hydatidiform mole (benign lesions group), and 31 cases with invasive hydatidiform mole (ma-lignant lesions group). Result The positive expression rates of TGF-β1 in invasive hydatidiform mole and choriocarcino-ma (58.1%) were significantly lower than that in benign lesions group (87.9%) and control group (97.0%) (P<0.05), while were similar between benign lesions and controls (P>0.05). As for PLGF, the patients with invasive hydatidiform mole and choriocarcinoma had higher positive expression rate (90.3%) than that in control group (36.4%) and benign lesions group (63.6%) (P<0.05), and it was comparable between benign lesions group and control group (P>0.05). Patients with age>40 years, hCG>105 U/L, and increased uterine volume had lower TGF-β1 expression (P<0.05) in benign and malig-nant lesions group;patients with theca lutein cyst diameter>6 cm or recurrent hydatidiform mole had similar positive ex-pression compared with those without the risk factors stated above (P>0.05). In benign and malignant lesions group, pa-tients with age>40 years, hCG>105 U/L, and increased uterine volume, or theca lutein cyst diameter>6 cm had higher PLGF expression rate than those without (P<0.05);and those with or without recurrent hydatidiform mole had consistent PLGF levels (P>0.05). There was a negative correlation between TGF-β1 and PLGF expression in patients benign and malignant lesions (P<0.05). Conclusion TGF-β1 and PLGF may become a new index of predicting malignant transfor-mation of hydatidiform mole which provides a basis for preventive chemotherapy.
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