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Efficacy observation of thrombocytopenia after chemotherapy by recombinant human interleukin 11 for treatment of acute leukemia
Author(s): Gao Lingxia, Ding Xiangmei, Ge Yan
Pages: 301-
302,304
Year: 2017
Issue:
5
Journal: Journal of Leukemia & Lymphoma
Keyword: 白血病; 急性; 重组人白细胞介素11; 血小板减少;
Abstract: 目的 观察重组人白细胞介素11(rhIL-11)治疗急性白血病患者化疗后引起血小板减少的效果和不良反应.方法 选取56例化疗后血小板减少的急性白血病患者分为治疗组和对照组,治疗组采用rhIL-1150μg·kg-1·d-1,对照组主要采用对症治疗.结果 血小板减少最低值治疗组为(35.56±5.32)×109/L,与对照组(30.31±3.96)×109/L比较,差异有统计学意义(t=7.99,P<0.05);血小板减少持续时间治疗组少于对照组[(7.60±2.43)d比(8.96±2.21)d],差异有统计学意义(t=2.24,P<0.05).患者主要不良反应为疲劳、注射部位疼痛、水肿、关节肌肉酸痛、心律失常、头晕等,绝大多为Ⅰ、Ⅱ度.结论 rhIL-11能有效地治疗因化疗引起的血小板减少,不良反应轻微,耐受性好.
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