Author(s): Guan Mingjun, Ren Xiaoyun, Wang Dalu, Yin Hongzhuan, Liang Yichao, Wu Di, Wang Heling, Su Qi
Pages: 1935-1937
Year: 2017 Issue:  12
Journal: Journal of Modern Oncology
Keyword:  colon cancer; immunohistochemica;
Abstract: Objective:To evaluate the expression of Rab25 in the colon cancer tissues and investigate its association with the clinicopathological features of colon cancer patient.Methods:The expression of Rab25 was examined in 56 surgical specimens of primary colonic carcinoma and 56 adjacent cancer tissues with immunohistochemistry method.The correlations of the Rab25 expression with clinicopathological parameters.Results:The positive rate of expression of Rab25 was 73.2%(41/56) in cancer tissues and 28.6%(16/56) in adjacent cancer tissues.There was an obvious statistical difference between the two groups(P<0.05).The Rab25 expression was significantly correlated with the histological grade,TNM stages and lymph node metastasis of colon cancer (P<0.05).The positive expression of Rab25 was significantly correlated with the differentiation,lymph node metastasisand and TNM stage(P<0.05).Conclusion:Rab25 is highly expressed in colon cancer tissues,which suggested that the abnormal high expression of Rab25 played an important role in the occurrence and development of colon cancer.