Retrospective analysis of genetic test in 90 patients with schizophrenia
Author(s): WANG Wei, LI Xianwei
Pages: 448-450
Year: 2016 Issue: 6
Journal: Journal of Psychiatry
Keyword: Schizophrenia; Genetic test; Cytochrome P450(CYP450); enzymes; Safety;
Abstract: Objective To explore the effects of polymorphisms detecting in cytochrome P450 (CYP450) enzymes relative to antipsychotics on treatment plan in schizophrenic inpatients.Methods All patients,observed and recorded in real state using real-world studies,were divided into allelic mutation group (n =42) and normal metabolism group (n =48) according to the genetic test results.They were assessed with Positive and Negative Syndrome Scale (PANSS),Treatment Emergent Symptoms Scale(TESS).The incidence rates of treatment plan changes in both groups were compared.Results 42 patients with 06CYP2D6* 10 were detected from 90 patients,and the remaining 48 cases were normal metabolic type;mutation rate of 06CYP2D6 * 10 was 46.7％.It was significantly different for both groups in the treatment plan changes after the genetic test(P ＜0.01).When discharged,the total scores of PANSS in both groups decreased significantly compared with those on admission (P ＜ 0.05).The incidence rate of adverse reactions in allelic mutation group was significantly higher than that in normal metabolism group after 1 week of admission(P ＜0.01).There was no significant difference in effective rates and incidence rates of adverse reactions between both groups when discharged (P ＞ 0.05).Conclusion The implementation of genetic test for schizophrenic inpatients can effectively assist the treatment system,which is worthy of promotion.
Pages: 448-450
Year: 2016 Issue: 6
Journal: Journal of Psychiatry
Keyword: Schizophrenia; Genetic test; Cytochrome P450(CYP450); enzymes; Safety;
Abstract: Objective To explore the effects of polymorphisms detecting in cytochrome P450 (CYP450) enzymes relative to antipsychotics on treatment plan in schizophrenic inpatients.Methods All patients,observed and recorded in real state using real-world studies,were divided into allelic mutation group (n =42) and normal metabolism group (n =48) according to the genetic test results.They were assessed with Positive and Negative Syndrome Scale (PANSS),Treatment Emergent Symptoms Scale(TESS).The incidence rates of treatment plan changes in both groups were compared.Results 42 patients with 06CYP2D6* 10 were detected from 90 patients,and the remaining 48 cases were normal metabolic type;mutation rate of 06CYP2D6 * 10 was 46.7％.It was significantly different for both groups in the treatment plan changes after the genetic test(P ＜0.01).When discharged,the total scores of PANSS in both groups decreased significantly compared with those on admission (P ＜ 0.05).The incidence rate of adverse reactions in allelic mutation group was significantly higher than that in normal metabolism group after 1 week of admission(P ＜0.01).There was no significant difference in effective rates and incidence rates of adverse reactions between both groups when discharged (P ＞ 0.05).Conclusion The implementation of genetic test for schizophrenic inpatients can effectively assist the treatment system,which is worthy of promotion.
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