Study of factors for amisulpride-induced marked prolactin elevation in schizopirenia
Author(s): WANG Li-hua, SUN Xiu-jia, LI Hua-fang
Pages: 131-133
Year: 2017 Issue: 2
Journal: Journal of Clinical Psychological Medicine
Keyword: schizopirenia; amisulpride; prolactin;
Abstract: Objective:To investigate the factors of amisulpride-induced marked prolactin elevation in schizophrenia. Method:A total of 48 patients with schizophrenia were enrolled and treated with amisupride for 8 weeks. Level of serum prolactin was measured at baseline,week 4,and 8. Plasma concentration of amisul-pride was measured at week 4,and 8. Patients were divided into two groups:marked prolactin elevation group and not marked prolactin elevation group by level of serum prolactin 1600 mIU/L at week 8. Two groups of de-mographic and clinical datas were compared to analyze the factors of amisulpride-induced marked prolactin ele-vation in schizophrenia. Results:24 patients are grouped into marked prolactin elevation group and 24 pa-tients are grouped into not marked prolactin elevation group. Compared with patients in not marked prolactin ele-vation group,the patients in marked prolactin elevation group were younger and prescribed higher doses of amisulpride and the ratio of women,prolactin elavation of baseline were significant higher (P <0. 05 or P <0. 01). The results of Logistic regression analysis indicated that the odds ratio of women was 13. 933(95%CI:2. 636-73. 648,P<0. 01),and the odds ratio of the basic level of prolactin above normal was 5. 728 (95%CI:1. 142-28. 741,P<0. 05). Conclusion:Women and the basic level of prolactin above normal are the risk factors of the marked prolactin elevation due to amisulpride in schizophrenia.
Pages: 131-133
Year: 2017 Issue: 2
Journal: Journal of Clinical Psychological Medicine
Keyword: schizopirenia; amisulpride; prolactin;
Abstract: Objective:To investigate the factors of amisulpride-induced marked prolactin elevation in schizophrenia. Method:A total of 48 patients with schizophrenia were enrolled and treated with amisupride for 8 weeks. Level of serum prolactin was measured at baseline,week 4,and 8. Plasma concentration of amisul-pride was measured at week 4,and 8. Patients were divided into two groups:marked prolactin elevation group and not marked prolactin elevation group by level of serum prolactin 1600 mIU/L at week 8. Two groups of de-mographic and clinical datas were compared to analyze the factors of amisulpride-induced marked prolactin ele-vation in schizophrenia. Results:24 patients are grouped into marked prolactin elevation group and 24 pa-tients are grouped into not marked prolactin elevation group. Compared with patients in not marked prolactin ele-vation group,the patients in marked prolactin elevation group were younger and prescribed higher doses of amisulpride and the ratio of women,prolactin elavation of baseline were significant higher (P <0. 05 or P <0. 01). The results of Logistic regression analysis indicated that the odds ratio of women was 13. 933(95%CI:2. 636-73. 648,P<0. 01),and the odds ratio of the basic level of prolactin above normal was 5. 728 (95%CI:1. 142-28. 741,P<0. 05). Conclusion:Women and the basic level of prolactin above normal are the risk factors of the marked prolactin elevation due to amisulpride in schizophrenia.
Related Articles