Effects of intensive atorvastatin on post-PCI inflammatory factor and renal function of CHD patients
Author(s): Li Zhifei, Zhou Jingui, Zhang Shuangyuan
Pages: 11-13,19
Year: 2017 Issue: 2
Journal: Journal of Clinical Psychosomatic Diseases
Keyword: Intensiveness; atorvastatin; CHD; PCI; inflammatory factor; renal function;
Abstract: Objective To explore the fffects of intensive atorvastatin on inflammatory factor and renal function of coronary heart disease (CHD) patients after percutaneous coronary intervention (PCI). Methods A total of 108 CHD patients were assigned to group A and B of 54 ones each according to random number table. Both groups received routine treatment in 1 week before operation,on this basis group A was plus routine dosage of atorvastatin and B plus intensive atorvastatin. Results After treatment C-reactive protein,interleukin-6 and tumor necrosis factor-α levels of both groups were significantly higher compared with pretreatment (P<0.05 or 0.01),so were those in group A than in B (P<0.01). After treatment urea nitrogen,serum creatinine and cystatin levels were significantly higher (P<0.01) and creatinine clearance and glomerular filtration rate lower (P<0.01) compared with pretreatment in group A;urea nitrogen,creatinine clearance and glomerular filtration rate were significantly higher and serum creatinine and cystatin levels lower (P<0.01) in B. After treatment urea nitrogen,serum creatinine and cystatin levels were significantly lower (P<0.01) and creatinine clearance and glomerular filtration rate higher (P<0.01) in group B than in A. There were no significant differences in the incidences of adverse reactions (P>0.05). Conclusion Intensive atorvastatin could notably lower post-PCI inflammatory factors levels of CHD patients and protect renal function.
Pages: 11-13,19
Year: 2017 Issue: 2
Journal: Journal of Clinical Psychosomatic Diseases
Keyword: Intensiveness; atorvastatin; CHD; PCI; inflammatory factor; renal function;
Abstract: Objective To explore the fffects of intensive atorvastatin on inflammatory factor and renal function of coronary heart disease (CHD) patients after percutaneous coronary intervention (PCI). Methods A total of 108 CHD patients were assigned to group A and B of 54 ones each according to random number table. Both groups received routine treatment in 1 week before operation,on this basis group A was plus routine dosage of atorvastatin and B plus intensive atorvastatin. Results After treatment C-reactive protein,interleukin-6 and tumor necrosis factor-α levels of both groups were significantly higher compared with pretreatment (P<0.05 or 0.01),so were those in group A than in B (P<0.01). After treatment urea nitrogen,serum creatinine and cystatin levels were significantly higher (P<0.01) and creatinine clearance and glomerular filtration rate lower (P<0.01) compared with pretreatment in group A;urea nitrogen,creatinine clearance and glomerular filtration rate were significantly higher and serum creatinine and cystatin levels lower (P<0.01) in B. After treatment urea nitrogen,serum creatinine and cystatin levels were significantly lower (P<0.01) and creatinine clearance and glomerular filtration rate higher (P<0.01) in group B than in A. There were no significant differences in the incidences of adverse reactions (P>0.05). Conclusion Intensive atorvastatin could notably lower post-PCI inflammatory factors levels of CHD patients and protect renal function.
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