Expression of Twist and E-cadherin in oral squamous cell carcinoma and its clinical significance
Author(s): Wu Hegang, Zhang Xu, Li Tianyong, Yuan Senfu, Guo Yu, Zhu Kunting
Pages: 1884-1887
Year: 2017 Issue: 12
Journal: Journal of Modern Oncology
Keyword: oral squamous cell carcinoma; immunohistochemistry;
Abstract: Objective:To investigate the expression of transcription factor Twist and epithelial cell calcium mucin(E-cadherin) in oral squamous cell carcinoma(OSCC) and to explore their relationship between with the occurrence and development of OSCC.Methods:Immunohistochemistry SP method was used to detected the expression of Twist and E-cadherin in 20 cases of normal oral mucosa tissues and 78 cases of OSCC tissues.Correlation between expression of Twist and E-cadherin in OSCC was analysed by Spearman rank correlation analysis.Results:The expression of Twist in OSCC tissues was significantly higher than normal oral mucosa tissues(P<0.05).The expression of E-cadherin in OSCC tissues was significantly lower than normal oral mucosa tissues(P<0.05).The expression of E-cadherin in OSCC tissues of stage Ⅲ and Ⅳ was lower than stage I and Ⅱ(P<0.05).The expression of E-cadherin in OSCC tissues of patients with lymph node metastasis was lower than that non metastasis(P<0.05).The expression of Twist in OSCC tissues of stage Ⅲ and Ⅳ was higher than stage I and Ⅱ(P<0.05).The expression of Twist in OSCC tissues of patients with lymph node metastasis was higher than that non metastasis(P<0.05).The expression of Twist in OSCC was negatively correlated with the expression of E-cadherin(r=-0.639,P<0.05).Conclusion:The abnormal expression of Twist and E-cadherin in OSCC tissues,and their expression was highly correlated,suggesting that they may participate in the occurrence and development of OSCC,invasion and metastasis.Combined detection of Twist and E-cadherin has great clinical values in the prevention,diagnosis,treatment and prognosis of OSCC.
Pages: 1884-1887
Year: 2017 Issue: 12
Journal: Journal of Modern Oncology
Keyword: oral squamous cell carcinoma; immunohistochemistry;
Abstract: Objective:To investigate the expression of transcription factor Twist and epithelial cell calcium mucin(E-cadherin) in oral squamous cell carcinoma(OSCC) and to explore their relationship between with the occurrence and development of OSCC.Methods:Immunohistochemistry SP method was used to detected the expression of Twist and E-cadherin in 20 cases of normal oral mucosa tissues and 78 cases of OSCC tissues.Correlation between expression of Twist and E-cadherin in OSCC was analysed by Spearman rank correlation analysis.Results:The expression of Twist in OSCC tissues was significantly higher than normal oral mucosa tissues(P<0.05).The expression of E-cadherin in OSCC tissues was significantly lower than normal oral mucosa tissues(P<0.05).The expression of E-cadherin in OSCC tissues of stage Ⅲ and Ⅳ was lower than stage I and Ⅱ(P<0.05).The expression of E-cadherin in OSCC tissues of patients with lymph node metastasis was lower than that non metastasis(P<0.05).The expression of Twist in OSCC tissues of stage Ⅲ and Ⅳ was higher than stage I and Ⅱ(P<0.05).The expression of Twist in OSCC tissues of patients with lymph node metastasis was higher than that non metastasis(P<0.05).The expression of Twist in OSCC was negatively correlated with the expression of E-cadherin(r=-0.639,P<0.05).Conclusion:The abnormal expression of Twist and E-cadherin in OSCC tissues,and their expression was highly correlated,suggesting that they may participate in the occurrence and development of OSCC,invasion and metastasis.Combined detection of Twist and E-cadherin has great clinical values in the prevention,diagnosis,treatment and prognosis of OSCC.
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