Author(s): Pan Hui, Hu Yibin, Guo Zhihua, Zhang Yalei, Yin Weiqiang, Zhang Jinxin
Pages: 85-91
Year: 2017 Issue:  2
Journal: Journal of Cancer Control and Treatment
Keyword:  Propensity score; Limited disease small cell lung cancer; Survival analysis; Operative; Adjuvant chemotherapy;
Abstract: Objective: To evaluate the therapeutic effects of surgical resection combined with adjuvant chemotherapy in the patients with limited disease small cell lung cancer(LD-SCLC) based on propensity score matching.Methods: Between 2009 and 2014, 61 surgical resections and 96 non-operatives were performed on patients with disease limited stage small cell lung cancer in our institute.Pretreatment clinical parameters including T stage, N stage, number of lesions and histology were used for propensity score matching.After propensity score matching, 30 operative patients and 30 non-operative patients were selected and compared.Results: The median survival time of operative group was 27 months(95%CI:2.73-51.26), and the other group was 14 months(95%CI:11.8-16.18).After propensity matching, two groups were similar in regards to important variables.The long-term survival time was significant different (27 months vs.17 months, P=0.001).Conclusion: The current propensity score analysis suggests that surgical resection combined with adjuvant chemotherapy can benefit the survival of patients with limited disease small cell lung cancer.