Procalcitonin inspection results in anti-infective therapy of AECOPD patients
Author(s): SHI Lei, SHI Yan, LUO Lin
Pages: 165-168
Year: 2017 Issue: 2
Journal: Clinical Journal of Medical Officer
Keyword: Procalcitonin; Chronic obstructive pulmonary disease; Acute exacerbation;
Abstract: Objective To investigate the value of the procalcitonin(PCT) inspection result,which conducted anti-infection therapy in patients with the acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A retrospective study was performed on 78 AECOPD patients received in No.210 Hospital of PLA from September 2015 to September 2016.Patients were randomly divided into the conventional group(n =39) and the PCT guided group(n =39).The therapeutic schedule of antibacterial agents in the conventional group was according to clinical feature,clinical guidance and clinician experience;in the PCT guided group,the serum PCT index was used as a guideline of antibacterial agents.The clinical indicators,effective rate,length of hospital stay,antibiotic treatment,hospitalization costs,antibacterial agents utilization rate,rate of disease progression and mortality,and co-infection rate between the two groups were observed.Results Mter the treatment,there was no statistical significance in the clinical indicators,effective rate,rate of disease progression and mortality between the two groups (P ＞ 0.05).The antibacterial agents utilization rate,length of hospital stay,hospitalization costs,course of treatment and co-infection rate in the PCT guided group were significantly lower than those in the conventional group(P ＜ 0.05),Conclusion The PCT inspection result has a guiding function towards the antibiotic treatment of AECOPD patients,it can shorten antibacterial drug use and the hospitalization time,effectively avoid the abuse of antibiotics and reduce co-infection.
Pages: 165-168
Year: 2017 Issue: 2
Journal: Clinical Journal of Medical Officer
Keyword: Procalcitonin; Chronic obstructive pulmonary disease; Acute exacerbation;
Abstract: Objective To investigate the value of the procalcitonin(PCT) inspection result,which conducted anti-infection therapy in patients with the acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A retrospective study was performed on 78 AECOPD patients received in No.210 Hospital of PLA from September 2015 to September 2016.Patients were randomly divided into the conventional group(n =39) and the PCT guided group(n =39).The therapeutic schedule of antibacterial agents in the conventional group was according to clinical feature,clinical guidance and clinician experience;in the PCT guided group,the serum PCT index was used as a guideline of antibacterial agents.The clinical indicators,effective rate,length of hospital stay,antibiotic treatment,hospitalization costs,antibacterial agents utilization rate,rate of disease progression and mortality,and co-infection rate between the two groups were observed.Results Mter the treatment,there was no statistical significance in the clinical indicators,effective rate,rate of disease progression and mortality between the two groups (P ＞ 0.05).The antibacterial agents utilization rate,length of hospital stay,hospitalization costs,course of treatment and co-infection rate in the PCT guided group were significantly lower than those in the conventional group(P ＜ 0.05),Conclusion The PCT inspection result has a guiding function towards the antibiotic treatment of AECOPD patients,it can shorten antibacterial drug use and the hospitalization time,effectively avoid the abuse of antibiotics and reduce co-infection.
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