Advancements in magnetic resonance imaging of cell apoptosis
Author(s): ZHANG Hongchun, CAI Sainan, TAN Na, LIAO Haiyan, ZHOU Bing, WANG Guotao, XIA Xibin
Pages: 317-320
Year: 2017 Issue: 3
Journal: International Journal of Medical Radiology
Keyword: Apoptosis imaging; Magnetic resonance imaging; Molecular imaging; Phosphatidylserine; Annexin V; Caspase-3;
Abstract: It is significant to detect apoptosis for detecting disease and assessing therapy efficiency at early stage. Recent years, many new MRI-based probes have improved the quality of MRI. Many small probes that target phosphatidylser-ine and demonstrate Caspase-3 activity are available to obtain superior tissue penetration. Molecular structures of many tra-ditional probes have been modified to improve the specific binding between probes and targets. A number of MRI-based probes, such as the Caspase-3 sensitive nano-aggregation MR probe (C-SNAM), have been used to improved signal strength of cell apoptosis in some degree.
Pages: 317-320
Year: 2017 Issue: 3
Journal: International Journal of Medical Radiology
Keyword: Apoptosis imaging; Magnetic resonance imaging; Molecular imaging; Phosphatidylserine; Annexin V; Caspase-3;
Abstract: It is significant to detect apoptosis for detecting disease and assessing therapy efficiency at early stage. Recent years, many new MRI-based probes have improved the quality of MRI. Many small probes that target phosphatidylser-ine and demonstrate Caspase-3 activity are available to obtain superior tissue penetration. Molecular structures of many tra-ditional probes have been modified to improve the specific binding between probes and targets. A number of MRI-based probes, such as the Caspase-3 sensitive nano-aggregation MR probe (C-SNAM), have been used to improved signal strength of cell apoptosis in some degree.
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