Surgical treatment for adult thalamus malignant glioma
Author(s): LI Xin, ZHANG Pengfei, HAN Lijiang, ZHANG Junting
Pages: 146-150
Year: 2017 Issue: 2
Journal: Chinese Journal of Neurosurgical Disease Research
Keyword: Glioma; Thalamus; Neurosurgical procedures; Neuronavigation; DTI;
Abstract: Objective The clinical characteristics and microsurgical treatment of adult unilateral thalamic glioma were investigated.Methods The clinical characteristics of 16 cases and the different approaches for surgery were analyzed,respectively.Diffusion Tensor Imaging (DTI) functional magnetic navigation was used in 10 patients.Subsequent chemoradiotherapy was applied in 15 cases post-operatively.Results Total resection of the tumor was achieved in 15 cases (94％) and subtotal resection in 1 case (6％).Post-operative improvement was achieved in 9 cases (56％) and unchanged in 7 cases (44％).Partial motor aphasia occurred in 1 case.Absence seizure occurred in 1 case.There was no surgery-related death.Ventriculoperitoneal shunt was performed in 2 cases of hydrocephalus;stereotactic puncture was performed in 1 case of post-operative tension effusion.The pathological examination confirmed 15 cases of Grade Ⅲ～ Ⅳ gliomas and 1 case of Grade Ⅱ glioma.Recurrence was occurred in 5 of 15patients (except 1 case) with subsequent chemoradiotherapy (3 ～ 16 months,average 9.8 months).Three patients died because of recurrence (survival time:13 ～20 months,average 17 months).Follow-up survival rate of 1 year and 2 years were 100％ and 81.0％,respectively.Progression free survival of 1 year and 2 year were 75.0％ and 62.5％,respectively.Conclusion It makes the morbidity and mortality of maximal surgical resection for patients with thalamic glioma decrease significantly due to the development of microsurgical technique and neuronavigation.It is the best choice for patients with thalamic glioma to perform maximal surgical resection and subsequent chemoradiotherapy.
Pages: 146-150
Year: 2017 Issue: 2
Journal: Chinese Journal of Neurosurgical Disease Research
Keyword: Glioma; Thalamus; Neurosurgical procedures; Neuronavigation; DTI;
Abstract: Objective The clinical characteristics and microsurgical treatment of adult unilateral thalamic glioma were investigated.Methods The clinical characteristics of 16 cases and the different approaches for surgery were analyzed,respectively.Diffusion Tensor Imaging (DTI) functional magnetic navigation was used in 10 patients.Subsequent chemoradiotherapy was applied in 15 cases post-operatively.Results Total resection of the tumor was achieved in 15 cases (94％) and subtotal resection in 1 case (6％).Post-operative improvement was achieved in 9 cases (56％) and unchanged in 7 cases (44％).Partial motor aphasia occurred in 1 case.Absence seizure occurred in 1 case.There was no surgery-related death.Ventriculoperitoneal shunt was performed in 2 cases of hydrocephalus;stereotactic puncture was performed in 1 case of post-operative tension effusion.The pathological examination confirmed 15 cases of Grade Ⅲ～ Ⅳ gliomas and 1 case of Grade Ⅱ glioma.Recurrence was occurred in 5 of 15patients (except 1 case) with subsequent chemoradiotherapy (3 ～ 16 months,average 9.8 months).Three patients died because of recurrence (survival time:13 ～20 months,average 17 months).Follow-up survival rate of 1 year and 2 years were 100％ and 81.0％,respectively.Progression free survival of 1 year and 2 year were 75.0％ and 62.5％,respectively.Conclusion It makes the morbidity and mortality of maximal surgical resection for patients with thalamic glioma decrease significantly due to the development of microsurgical technique and neuronavigation.It is the best choice for patients with thalamic glioma to perform maximal surgical resection and subsequent chemoradiotherapy.
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