Author(s): ZHANG Rongjun, WANG Xiaofeng, TANG Zongchun, LUO Wenying, WANG Jun, WANG Baojiang, CHEN Bobo, ZHANG Yang, LI Xiaowei, LI Hu, GAO Fei
Pages: 124-127
Year: 2017 Issue:  2
Journal: Chinese Journal of Neurosurgical Disease Research
Keyword:  Traumatic brain injury; Hyponatremia; Cerebral salt wasting syndrome; Syndrome of inappropriate antidiuretic hormone secretion;
Abstract: Objective The etiology,pathogenesis,clinical features and treatment of hyponatremia in patients with traumatic brain injury were discussed.Methods The clinical manifestations,laboratory tests and clinical features of 137 cases with traumatic brain injury and hyponatremia treated in the past five year were analyzed retrospectively and the diagnosis and treatment of the patients were discussed.Results Hyponatremia after traumatic brain injury was divided into cerebral salt wasting syndrome (CSWS) and syndrome of inappropriate antidiuretic hormone secretion (SIADH) with the symptoms such as hyponatremia,unconsciousness,headache,dizziness,nausea and vomiting,etc.However,hypovolemia and decreased central venous pressure occurred in CSWS patients,and the increased blood volume and increased central venous pressure were observed in SIADH patients.In this group 123patients were cured and 14 died.Conclusion The pathogenesis and treatment of hyponatremia in patients with traumatic brain injury is different,and central venous pressure monitoring can identify CSWS and SIADH.Water restrictions and salt supplement are the most simple and effective methods to identify CSWS and SIADH.Early diagnosis and treatment can reduce the morbidity and mortality of these patients.