The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit
later.
We apologize for any inconvenience caused
Retrospective study of clinical and electrophysiological features in patients with typical and atypical chronic inflammatory demyelinating polyneuropathy
Author(s): Han Ya, Wang Jiahua, Lu Zuneng
Pages: 126-
129,135
Year: 2017
Issue:
2
Journal: Stroke and Nervous Diseases
Keyword: CIDP; Clinical Features; Electrophysiology;
Abstract: Objective To retrospectively analyze the clinical and electrophysiological features of patients with chronic inflammatory demyelinating polyneuropathy (CIDP).Methods Fourty-six consecutive patients who were referral to Department of Neurology,Renmin Hospital of Wuhan University,from January 2012 to December 2014,with clinical probable diagnosis of CIDP,were enrolled.The patients were divided into two groups,i.e.typical and atypical CIDP,according to the recommendations of European Federation of Neurological Societies (EFNS)/Peripheral Nerve Society (PNS) guidelines in 2010.The clinical and electrophysiological data were retrospectively analyzed.Results (1) Among 46 patients who conformed with the inclusion criteria,there were 27 males and 19 females,onset aged from 12~77 (52±15) years old.There were 33 patients with illness duration of more than 2 months,and 13 cases with illness duration of 2 months or less than 2 months;in which there were 6 patients with acute-onset,i.e.A-CIDP.(2) There were 28 patients (61%) with typical and 18 cases (39%) with atypical CIDP.The protein content of cerebrospinal fluid was (1.17±0.77) g/L in the group of typical CIDP and (0.92±0.53) g/L in atypical one (t=2.39,P=0.01).In typical and atypical CIDP groups,the distal CMAP amplitude of median,ulnar and tibial nerves were (5.30±3.34) mV vs (7.18±2.60) mV (t=2.14;P=0.04),(4.74±3.00) mV vs (7.99±3.62) mV(t=3.17,P=0.003) and (2.89±2.58) mV vs (7.18±4.71) (t=3.20,P=0.004);the sensory conduction velocity of median nerve,(49.82±11.68) m/s vs (56.81±7.27) m/s (t=2.11,P=0.04);the SNAP amplitude of sural nerve,(6.08±2.62) μV vs (10.40±5.62) μV (t=2.63,P=0.01),respectively.Conclusion Typical CIDP is still the predominant type clinically.Compared with the atypical CIDP,the typical CIDP patients have higher protein content of cerebrospinal fluid,slower motor and sensory conduction velocities with lower amplitudes,in which these biomarkers may be of certain distinguishing significance.
Citations
No citation found
Related Articles
No related articles found