Acute myeloid leukemia with NPM-MLF1 fusion gene: report of one case and review of literature
Author(s): Zhang Gangji, Li Wei, Qiu Shaowei, Wei Shuning, Liu Kaiqi, Liu Yuntao, Gong Benfa, Gu Runxia, Gong Xiaoyuan, Liu Bingcheng, Zhou Chunlin, Wei Hui, Wang Ying, Lin Dong, Mi Yingchang, Wang Jianxiang
Pages: 283-286
Year: 2017 Issue: 5
Journal: Journal of Leukemia & Lymphoma
Keyword: Leukemia; myeloid; acute; Gene fusion; Translocation; genetic; Prognosis;
Abstract: Objective To investigate the characteristics of NPM-MLF1 fusion gene in acute myeloid leukemia (AML). Methods The data of one AML patient with NPM-MLF1 fusion gene was analyzed,and literatures were reviewed. Results A female patient was diagnosed as AML M6. In the course of the disease, 2 hematologic relapsed, and 2 recurrences were associated with NPM-MLF1 fusion gene positive. After inductive treatment, hematologic complete remission was achieved, and NPM-MLF1 fusion genes were all negative. Survival time surpassed 6 years when the chemotherapy was performed alone. Conclusion The incidence of NPM-MLF1 fusion gene in AML is low. It is necessary to collect more clinical data to judge whether an independent disease type or not.
Pages: 283-286
Year: 2017 Issue: 5
Journal: Journal of Leukemia & Lymphoma
Keyword: Leukemia; myeloid; acute; Gene fusion; Translocation; genetic; Prognosis;
Abstract: Objective To investigate the characteristics of NPM-MLF1 fusion gene in acute myeloid leukemia (AML). Methods The data of one AML patient with NPM-MLF1 fusion gene was analyzed,and literatures were reviewed. Results A female patient was diagnosed as AML M6. In the course of the disease, 2 hematologic relapsed, and 2 recurrences were associated with NPM-MLF1 fusion gene positive. After inductive treatment, hematologic complete remission was achieved, and NPM-MLF1 fusion genes were all negative. Survival time surpassed 6 years when the chemotherapy was performed alone. Conclusion The incidence of NPM-MLF1 fusion gene in AML is low. It is necessary to collect more clinical data to judge whether an independent disease type or not.
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