Expressions of CCL20, CCR6 and IL-17A in Serum of Patients with Psoriasis Vulgaris
Author(s): Wang Xiaoqin, Mu Zhenzhen, Han Xiuping
Pages: 122-124
Year: 2017 Issue: 2
Journal: Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine
Keyword: Interleukin-17A; Psoriasis;
Abstract: Objective In order to investigate the expressions of CCL20,CCR6 and IL-17A in serum of patients with psoriasis vulgaris,as well as their clinical implications.Methods Serum concentrations of CCL20,CCR6 and IL-17A were detected by ELISA in 26 patients with plaque psoriasis,7 guttate psoriasis patients and 8 healthy people.Correlations of CCL20,CCR6 and IL-17A with PASI scores and courses of disease were analyzed.Results The concentrations of CCL20,CCR6 and IL-17A in patients with plaque psoriasis (748.74±268.72,10.20 ±3.75,39.22± 13.21) were significantly higher than those in normal controls (578.45±204.93,6.79±4.61,25.54±13.04) (P＜0.05,＜0.01,＜0.01 respectively).There was no difference between guttate psoriasis patients and normal controls.The concentrations of CCL20 and CCR6 were positively correlated with PASI (r=0.416,r=0.350) (all P＜0.05).CCL20,CCR6 and IL-17A were significantly positively correlated with each other (r=0.852,r=0.801,r=0.825) (all P＜0.001),but had no relation with the course of disease (all P＞0.05).Conclusion CCL20,CCR6 and IL-17A might be involved in the pathogenesis of plaque psoriasis.
Pages: 122-124
Year: 2017 Issue: 2
Journal: Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine
Keyword: Interleukin-17A; Psoriasis;
Abstract: Objective In order to investigate the expressions of CCL20,CCR6 and IL-17A in serum of patients with psoriasis vulgaris,as well as their clinical implications.Methods Serum concentrations of CCL20,CCR6 and IL-17A were detected by ELISA in 26 patients with plaque psoriasis,7 guttate psoriasis patients and 8 healthy people.Correlations of CCL20,CCR6 and IL-17A with PASI scores and courses of disease were analyzed.Results The concentrations of CCL20,CCR6 and IL-17A in patients with plaque psoriasis (748.74±268.72,10.20 ±3.75,39.22± 13.21) were significantly higher than those in normal controls (578.45±204.93,6.79±4.61,25.54±13.04) (P＜0.05,＜0.01,＜0.01 respectively).There was no difference between guttate psoriasis patients and normal controls.The concentrations of CCL20 and CCR6 were positively correlated with PASI (r=0.416,r=0.350) (all P＜0.05).CCL20,CCR6 and IL-17A were significantly positively correlated with each other (r=0.852,r=0.801,r=0.825) (all P＜0.001),but had no relation with the course of disease (all P＞0.05).Conclusion CCL20,CCR6 and IL-17A might be involved in the pathogenesis of plaque psoriasis.
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