Author(s): Li Qiyong
Pages: 42-44
Year: 2017 Issue:  2
Journal: Journal of Clinical Psychosomatic Diseases
Keyword:  MDA; aripiprazole; paliperidone; PANSS; TESS;
Abstract: Objective To explore the efficacy and safety of aripiprazole vs. paliperidone in the treatment of mental disorders due to alcohol (MDA). Methods According to toss 86 MDA patients were assigned to two groups taking orally aripiprazole or paliperidone for 6 weeks. Efficacies were assessed with the Positive and Negative Syndrome Scale (PANSS) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS). Results At the end of the 6th week effective and total effective rate were respectively 88.6% and 97.7% in aripiprazole and 88.1% and 95.2% in paliperidone group,which showed no significant differences (P>0.05). Since the 2nd week the total PANSS scores of both groups lowered more significantly compare with pretreatment (P<0.01) and group difference wasn't significant in the corresponding period. The incidence of adverse reactions was respectively 31.8% in aripiprazole and 28.5% in paliperidone group and group difference wasn't significant (P>0.05). Conclusion Both aripiprazole and paliperidone have an evident effect,higher safety and better compliance in MDA.