The mechanism of heat-induced damage of endothelial cells and its effect on vital organs
Author(s): SU Lei, GU Zheng-tao, Department of Intensive Care Unit, Guangzhou General Hospital of Guangzhou Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA
Pages: 271-278
Year: 2017 Issue: 4
Journal: Medical Journal of Chinese People's Liberation Army
Keyword: heat stroke; endothelial cells; microcirculation; multiple organ failure;
Abstract: As an important organ of the human body, vascular endothelial cells(VECs) play a vital role in heat stress-induced tissue damage. Its integrity not only serves as a barrier for maintaining vascular permeability but also has major impact on cellular structure and function during acute phase response to heat stress. In heat stroke, a series of acute and complicated pathophysiological changes, including microcirculation change, damage VECs and thereby induce or aggravate multiple organ dysfunction syndrome(MODS). Meanwhile, studies have shown that, during heat stroke, VECs are the major responding cells and one of the most common cells that experience morphological and functional changes. Therefore, VECs damage might be an important mechanism involved in heat stroke. This article reviews the mechanism of heat-induced damage of VECs and its effect on vital organs.
Pages: 271-278
Year: 2017 Issue: 4
Journal: Medical Journal of Chinese People's Liberation Army
Keyword: heat stroke; endothelial cells; microcirculation; multiple organ failure;
Abstract: As an important organ of the human body, vascular endothelial cells(VECs) play a vital role in heat stress-induced tissue damage. Its integrity not only serves as a barrier for maintaining vascular permeability but also has major impact on cellular structure and function during acute phase response to heat stress. In heat stroke, a series of acute and complicated pathophysiological changes, including microcirculation change, damage VECs and thereby induce or aggravate multiple organ dysfunction syndrome(MODS). Meanwhile, studies have shown that, during heat stroke, VECs are the major responding cells and one of the most common cells that experience morphological and functional changes. Therefore, VECs damage might be an important mechanism involved in heat stroke. This article reviews the mechanism of heat-induced damage of VECs and its effect on vital organs.
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