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Distribution and Drug Resistance of Pathogenic Bacteria in Patients with Urinary Tract Infection
Author(s): Qiu Guang-fu, Xie Qun, Zhao Xi-yuan, Li Hua-fu, Department of Urology, Zhuhai People’s Hospital Affiliated to Jinan University, Clinical Laboratory, Zhuhai People’s Hospital Affiliated to Jinan University
Pages: 1-
5
Year: 2017
Issue:
3
Journal: China Licensed Pharmacist
Keyword: Urinary Tract Infection; Urine Culture; Pathogenic Bacteria; Drug Resistance;
Abstract: Objective:To analyze the distribution and drug resistance of pathogenic bacteria in patients with urinary tract infection in Zhuhai Region and provide a basis for reasonable usage of antibiotics in clinic. Methods:A total of 596 strains of pathogenic bacteria were cultured from the midstream urine samples of outpatients and inpatients with symptoms of urinary tract infection symptoms in Zhuhai People’s Hospital Affiliated to Jinan University from Oct 2015 to Oct 2016 and subjected to drug sensitivity test in vitro. Results:Of the 596 strains of pathogenic bacteria, 420 strains(70.5%) were gram negative, 126(21.1%) were gram positive, and 50(8.4%) were fungi. The strains ranking the top three of the bacterial constitution were Escherichia coli(42.4%, 253/596), Enterococci(10.3%, 61/596) and Klebsiella pneumoniae(7.9%, 47/596). The fungi were mainly Candida tropicalis(3.5%, 21/596) and Candida glabrata(3.4%, 20/596). The pathogenic bacterial strains showed varying degrees of resistance to frequently-used antimicrobial agents. Escherichia coli showed high resistance rates to Penicillins, Cephalosporins and quinolones(52.6%~82.6%). Imipenem-resistant Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were isolated. Staphylococcus showd high resistance rates to Penicillins, Cephalosporins and beta-lactamase inhibitor antibiotics(40.0%~82.9%). Vancomycin-resistant Enterococcus faecalis was detected. Conclusion:In Zhuhai People’s Hospital, gram negative bacteria are the main pathogens of urinary tract infection while Escherichia coli is the most common pathogen, which are similar to those in domestic literature reports. The pathogenic bacteria of urinary tract infection have a certain resistance to frequently-used antimicrobial agents, and imipenem-and vancomycin-resistant pathogens were detected. Therefore, clinician should pay attention to the bacterial cultivation of patients with urinary tract infection so as to understand the distribution of pathogens and the drug resistance. In order to slowing the progress of drug resistant strains, the usage of antibiotics should be based on the results of drug sensitivity test as far as possible.
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