Influence of dexmedetomidine on the multimodal analgesic effect of flurbiprofen axetil
Author(s): HAN Xue, LIU Ling, ZHANG Guanghua
Pages: 274-277
Year: 2017 Issue: 6
Journal: Chinese Journal of Clinical Oncology
Keyword: dexmedetomidine; flurbiprofen axetil; multimodal analgesia; preemptive analgesia;
Abstract: Objective:To observe the influence of dexmedetomidine on the multimodal analgesic effect of flurbiprofen axetillon pa-tients subjected to radical resection of rectal carcinoma. Methods:Ninety patients who underwent abdominal resection of rectal carci-noma were selected and randomly divided into three groups (30 patients in each group). The patients in groups A and B were intrave-nously injected with flurbiprofen axetil 30 min before operation to achieve preemptive analgesia, while the patients in group C were pretreated with 2 mL lipid emulsion through intravenous injection. Patient-controlled intravenous analgesia pump was prepared as fol-lows:flurbiprofen axetil+dexmedetomidine+sufentanil for group A;flurbiprofen axetil+sufentanil for group B;and sufentanil+10 mL lipid emulsion for group C. The three groups were added with saline to obtain the final volume of 100 mL. The flow rate of the anal-gesic pump was 1 mL/h with single press amount of 1 mL and lock time of 15 min. Visual analog scale (VAS) while coughing and Ram-say sedation scores were recorded at 4 h (T1), 8 h (T2), 12 h (T3), 24 h (T4), and 48 h (T5) after operation. The effective press times and dosage of sufentanil were recorded for 24 h after operation, blood glucose level 30 min before and after operation, and C-reactive pro-tein (CRP) 48 h before and after operation were also monitored. The number of patients with enhanced analgesia and adverse reac-tions, such as nausea and vomiting, dizziness, headache, itchy skin, urinary retention, respiratory depression, and bradycardia, was re-corded for 48 h after operation. Results:Ramsay sedation scores of group A at T1 and T2 were higher than those of groups B and C. The VAS scores at T1, T2, and T3 while coughing, effective pumping time of the analgesic pump, post-operational blood glucose level, sufentanil consumption, and CRP of group A were lower than those of groups B and C (P<0.05). The number of adverse reactions in group A was not significantly different from that in group B. By comparison, this parameter was significantly lower than that in group C (P<0.05). The enhanced analgesia did not also significantly differ among the three groups. Conclusion:Dexmedetomidine combined with flurbiprofen axetil can induce multimodal analgesia, enhance analgesic effects, and reduce stress and inflammatory responses without the risk of increasing the incidence of adverse reactions.
Pages: 274-277
Year: 2017 Issue: 6
Journal: Chinese Journal of Clinical Oncology
Keyword: dexmedetomidine; flurbiprofen axetil; multimodal analgesia; preemptive analgesia;
Abstract: Objective:To observe the influence of dexmedetomidine on the multimodal analgesic effect of flurbiprofen axetillon pa-tients subjected to radical resection of rectal carcinoma. Methods:Ninety patients who underwent abdominal resection of rectal carci-noma were selected and randomly divided into three groups (30 patients in each group). The patients in groups A and B were intrave-nously injected with flurbiprofen axetil 30 min before operation to achieve preemptive analgesia, while the patients in group C were pretreated with 2 mL lipid emulsion through intravenous injection. Patient-controlled intravenous analgesia pump was prepared as fol-lows:flurbiprofen axetil+dexmedetomidine+sufentanil for group A;flurbiprofen axetil+sufentanil for group B;and sufentanil+10 mL lipid emulsion for group C. The three groups were added with saline to obtain the final volume of 100 mL. The flow rate of the anal-gesic pump was 1 mL/h with single press amount of 1 mL and lock time of 15 min. Visual analog scale (VAS) while coughing and Ram-say sedation scores were recorded at 4 h (T1), 8 h (T2), 12 h (T3), 24 h (T4), and 48 h (T5) after operation. The effective press times and dosage of sufentanil were recorded for 24 h after operation, blood glucose level 30 min before and after operation, and C-reactive pro-tein (CRP) 48 h before and after operation were also monitored. The number of patients with enhanced analgesia and adverse reac-tions, such as nausea and vomiting, dizziness, headache, itchy skin, urinary retention, respiratory depression, and bradycardia, was re-corded for 48 h after operation. Results:Ramsay sedation scores of group A at T1 and T2 were higher than those of groups B and C. The VAS scores at T1, T2, and T3 while coughing, effective pumping time of the analgesic pump, post-operational blood glucose level, sufentanil consumption, and CRP of group A were lower than those of groups B and C (P<0.05). The number of adverse reactions in group A was not significantly different from that in group B. By comparison, this parameter was significantly lower than that in group C (P<0.05). The enhanced analgesia did not also significantly differ among the three groups. Conclusion:Dexmedetomidine combined with flurbiprofen axetil can induce multimodal analgesia, enhance analgesic effects, and reduce stress and inflammatory responses without the risk of increasing the incidence of adverse reactions.
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