Author(s): ZHOU Meng, LIU Baoguo, GU Jing, MIAO Guoying, LI Xiaojing, LIU Qing
Pages: 132-136
Year: 2017 Issue:  3
Journal: China journal of Leprosy and Skin Diseases
Keyword:  Squamous cell carcinoma; Bowen's disease; actinic keratosis;
Abstract: Objective:To detect the expression of Raptor,Rictor and p-Akt in the lesions of actinic keratosis (AK),Bowen's disease (BD) and squamous cell carcinoma (SCC).Methods:Immunohistochemistry was used to detect the expression of Raptor,Rictor,p-Akt (Ser473) in the tissue samples from the patients with AK,BD,SCC and normal human skin.Results:The positivity rates of Raptor in SCC,BD and AK were 87.50%,70.00% and 60.00%,which was significantly higher than that in normal skin (Ps<0.05).The positivity rate was 100% in poorly differentiated squamous cell carcinoma and 75% in well differentiated squamous cell carcinomas,with a significant difference (P<0.05).The positivity rates of Rictor in SCC,BD and AK were 80.00%,70.00% and 55.00%,which was significantly higher than that in normal skin (P<0.05).The positivity rates of p-Akt (Ser473) in SCC,BD and AK were 77.50%,65.00% and 50.00%,while there was no positive staining in normal skin.There was a positive correlation between the expression level of Rictor and p-Akt (Ser473) in SCC,BD and AK (P<0.05).Conclusion:The high expression of Raptor,Rictor and p-Akt (Ser473) may play a key role in the occurrence and development of AK,BD and SCC.