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Progress on apatinib for solid tumors
Author(s): JIANG Chang, MIAO Yuqing, WANG Zhan, WANG Jiejun
Pages: 281-
284
Year: 2017
Issue:
3
Journal: Chinese Clinical Oncology
Keyword: Gastric cancer; Lung cancer; Breast cancer; Apatinib; VEGFR-2;
Abstract: Angiogenesis play an important role in the process of cell growth,and it is one of the basic characteristics of malignant tumors.So,antiangiogenesis is an effective way to anti-tumor.Apatinib is a novel small-molecule vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor.Through specific inhibition of vascular endothelial cells factor-2 tyrosine kinase activity,apatinib plays antiangiogenic and antitumor roles.Apatinib has demonstrated encouraging anticancer activity across a broad range of malignancies,including gastric cancer,breast cancer,non-small cell lung cancer,hepatocarcinoma and soft tissue tumor etc.This paper will make a review of clinical trials of apatinib to some solid tumors and provides reference for clinical practice in therapeutic options for cancer patients.
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