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The clinical analysis of homocysteine and insulin resistance in acute cerebral infarction elderly patients with obstr-active sleep apnea-hypopnea syndrome
Author(s): LI Gang, HU Yamei, LIU Jianfeng, ZHANG Hongju, XIANG Li, HOU Yahui, JIN Peijun, LUO Zhiyun
Pages: 126-
129
Year: 2017
Issue:
2
Journal: Journal of Apoplexy and Nervous Diseases
Keyword: Acute cerebral infarction; Obstructive sleep apnea syndrome; Homocysteine; Insulinresistance; Elderly;
Abstract: Objective To investigate the levels of homocysteine (Hcy) and insulin resistance in acute cerebral in-farction (ACI) elderly patients with obstractive sleep apnea syndrome (OSAHS),and analysis the relationships of them . Methods The participants were divided into the elderly ACI ﹢OSAHS group (n=21),elderly ACI group (n=30),mid-dle-aged ACI﹢OSAHS group (n=28) and middle-aged ACI group (n=34) according to the age and results of polysom-nography.The serum Hcy and insulin resistance(HOMA-IR) were detected,then analysis the relationship of OSAHS,Hcy and HOMA-IR.Results The Hcy and HOMA-IR levels in elderly ACI﹢OSAS group were higher than this in other groups (P<0.05);the Hcy and HOMA-IR levels in middle-aged ACI﹢OSAS group were higher than this in middle-aged ACI groups (P<0.05);the Hcy levels were positively correlated with the age ,AHI,waist circumference,BMI and HOMA-IR levels;and the AHI were positively correlated with the age ,Hcy,HOMA-IR levels and BMI.Conclusion The Hcy and HO-MA-IR levels increased with the advancing age in ACI elderly patients with OSAHS;OSAHS may affect the Hcy and insulin resistance levels ,then causes ACI .
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