The impact of type 2 diabetes mellitus on prognosis of non-small cell lung cancer with brain metastases
Author(s): Wang Lili, Liu Qun, Yin Qiang, Sun Zengfeng, She Chunhua, Li Wenliang
Pages: 265-269
Year: 2017 Issue: 3
Journal: Chinese Journal of Neurosurgery
Keyword: Carcinoma; non-small-cell lung; Diabetes mellitus; type 2; Prognosis; Brain metastasis;
Abstract: Objective To investigate the impact of type 2 diabetes mellitus (DM) on prognosis of non-small cell lung cancer with brain metastases.Methods We retrospectively reviewed the clinical data of 406 patients,who were diagnosed as non-small cell lung cancer with brain metastases and admitted to the departments of brain tumor,radiation therapy,pulmonary medicine and pulmonary surgery at Tianjin University Cancer Institute & Hospital from October 2010 to May 2015.Log-rank analysis and Cox regression model were used to identify prognostic factors of non-small cell lung cancer with brain metastases and the impact of type 2 DM on the overall survival (OS) and progression-free survival (PFS).Results Univariate analysis of OS revealed that age,lymph node staging,DM,chemotherapy,Karnofsky performance score had statistical significance (all P ＜ 0.05).Univariate analysis of PFS revealed that lymph node staging,DM,chemotherapy had statistical significance (all P ＜ 0.05).Multivariate analysis showed that presence of DM (OR,0.203,95％ CI0.067-0.618,P=0.005),lymph node staging (OR,0.573,95％ CI 0.420-0.781,P＜0.001) and age (OR,0.609,95％ CI 0.409-0.907,P =0.015) were considered independent prognostic factors for OS (P ＜ 0.05).In addition,DM (OR,0.317,95 ％ CI 0.112-0.900,P =0.031),lymph node staging (OR,0.723,95％ CI 0.556-0.941,P =0.016) and chemotherapy (OR,0.450,95％ CI 0.253-0.798,P =0.006) were identified as independent prognostic factors for PFS (P ＜ 0.05).Conclusion It is suggested that a history of type 2 DM might be correlated with increased OS and PFS in patients with NSCLC with brain metastases.
Pages: 265-269
Year: 2017 Issue: 3
Journal: Chinese Journal of Neurosurgery
Keyword: Carcinoma; non-small-cell lung; Diabetes mellitus; type 2; Prognosis; Brain metastasis;
Abstract: Objective To investigate the impact of type 2 diabetes mellitus (DM) on prognosis of non-small cell lung cancer with brain metastases.Methods We retrospectively reviewed the clinical data of 406 patients,who were diagnosed as non-small cell lung cancer with brain metastases and admitted to the departments of brain tumor,radiation therapy,pulmonary medicine and pulmonary surgery at Tianjin University Cancer Institute & Hospital from October 2010 to May 2015.Log-rank analysis and Cox regression model were used to identify prognostic factors of non-small cell lung cancer with brain metastases and the impact of type 2 DM on the overall survival (OS) and progression-free survival (PFS).Results Univariate analysis of OS revealed that age,lymph node staging,DM,chemotherapy,Karnofsky performance score had statistical significance (all P ＜ 0.05).Univariate analysis of PFS revealed that lymph node staging,DM,chemotherapy had statistical significance (all P ＜ 0.05).Multivariate analysis showed that presence of DM (OR,0.203,95％ CI0.067-0.618,P=0.005),lymph node staging (OR,0.573,95％ CI 0.420-0.781,P＜0.001) and age (OR,0.609,95％ CI 0.409-0.907,P =0.015) were considered independent prognostic factors for OS (P ＜ 0.05).In addition,DM (OR,0.317,95 ％ CI 0.112-0.900,P =0.031),lymph node staging (OR,0.723,95％ CI 0.556-0.941,P =0.016) and chemotherapy (OR,0.450,95％ CI 0.253-0.798,P =0.006) were identified as independent prognostic factors for PFS (P ＜ 0.05).Conclusion It is suggested that a history of type 2 DM might be correlated with increased OS and PFS in patients with NSCLC with brain metastases.
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