Neuronal firing rate and oscillatory activity in subthalamic nucleus associated with Parkinson 's disease progression
Author(s): Wen Yi, Zhuang Ping, Du Gang, Zhang Yuqing, Hu Yongsheng, Li Jianyu, Li Yongjie
Pages: 280-284
Year: 2017 Issue: 3
Journal: Chinese Journal of Neurosurgery
Keyword: Parkinson disease; Subthalamic nucleus; Microelectrodes; Neurons; Neuronal firing rate; Oscillatory activity;
Abstract: Objective To explore whether neuronal firing rate and proportion of oscillatory neuronal activity in subthalamic nucleus (STN) is associated with Parkinson's disease (PD) progression.Methods Twenty-two patients with PD treated with STN deep brain stimulation (DBS) at Beijing Institute of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University from March 2015 to March 2016 were analyzed retrospectively.Microelectrode recording was performed in the STN.Single unit analysis including interspike interval (ISI) was used to study neuronal firing rate and patterns.Power spectral analysis was used to evaluate neuronal oscillation.Clinical outcome was assessed using Unified Parkinson's Disease Rating Scales (UPDRS Ⅲ) pre-and post-surgery.The groups of the early stage and the advanced-stage were defined based on the UPDRS Ⅲ scores,disease duration and the side of initial symptoms.Results Of total 163 neurons identified from 32 STN,there were 66 neurons with mean firing rate of 46.2 ± 13.6 Hz obtained from the patients in the early-stage group whereas 97 neurons with mean firing rate of 59.9 ± 17.1 Hz were obtained from patients in the advanced-stage group.Power spectral analysis showed that there were 27 (40.9％) oscillatory neurons identified from the STN neurons in the early-stage patient group (n =66) whereas 55 (56.7％) oscillatory neurons were identified from the STN neurons in the advanced-stage patient group (n =95).Further analysis found that 29.7％ (8/27) β oscillatory neurons were observed in the early stage group whereas 52.7％ (29/55) β oscillatory neurons were observed in the advanced stage group.When comparing the mean firing rate and proportion of oscillatory neurons in the STN of early-stage group with that of neurons in the STN of advanced-stage group,it was found that there was a 29.6％ increase STN mean firing rate of neurons (46.2 ± 13.6 Hz vs.59.9 ± 17.1 Hz,P ＜ 0.05) and a 36.8％ increase proportion of oscillatory neurons (40.9％ vs.56.7％) between the two groups.In particular,a 77.8％ increase proportion of β oscillatory neurons was obtained between the early-stage and advanced-stage groups (29.7％ vs.52.8％,P ＜ 0.01).Conclusion The results strongly suggest that both subthalamic nucleus neuronal firing rate and proportion of β oscillatory neurons increase with PD progression.
Pages: 280-284
Year: 2017 Issue: 3
Journal: Chinese Journal of Neurosurgery
Keyword: Parkinson disease; Subthalamic nucleus; Microelectrodes; Neurons; Neuronal firing rate; Oscillatory activity;
Abstract: Objective To explore whether neuronal firing rate and proportion of oscillatory neuronal activity in subthalamic nucleus (STN) is associated with Parkinson's disease (PD) progression.Methods Twenty-two patients with PD treated with STN deep brain stimulation (DBS) at Beijing Institute of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University from March 2015 to March 2016 were analyzed retrospectively.Microelectrode recording was performed in the STN.Single unit analysis including interspike interval (ISI) was used to study neuronal firing rate and patterns.Power spectral analysis was used to evaluate neuronal oscillation.Clinical outcome was assessed using Unified Parkinson's Disease Rating Scales (UPDRS Ⅲ) pre-and post-surgery.The groups of the early stage and the advanced-stage were defined based on the UPDRS Ⅲ scores,disease duration and the side of initial symptoms.Results Of total 163 neurons identified from 32 STN,there were 66 neurons with mean firing rate of 46.2 ± 13.6 Hz obtained from the patients in the early-stage group whereas 97 neurons with mean firing rate of 59.9 ± 17.1 Hz were obtained from patients in the advanced-stage group.Power spectral analysis showed that there were 27 (40.9％) oscillatory neurons identified from the STN neurons in the early-stage patient group (n =66) whereas 55 (56.7％) oscillatory neurons were identified from the STN neurons in the advanced-stage patient group (n =95).Further analysis found that 29.7％ (8/27) β oscillatory neurons were observed in the early stage group whereas 52.7％ (29/55) β oscillatory neurons were observed in the advanced stage group.When comparing the mean firing rate and proportion of oscillatory neurons in the STN of early-stage group with that of neurons in the STN of advanced-stage group,it was found that there was a 29.6％ increase STN mean firing rate of neurons (46.2 ± 13.6 Hz vs.59.9 ± 17.1 Hz,P ＜ 0.05) and a 36.8％ increase proportion of oscillatory neurons (40.9％ vs.56.7％) between the two groups.In particular,a 77.8％ increase proportion of β oscillatory neurons was obtained between the early-stage and advanced-stage groups (29.7％ vs.52.8％,P ＜ 0.01).Conclusion The results strongly suggest that both subthalamic nucleus neuronal firing rate and proportion of β oscillatory neurons increase with PD progression.
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