Small regulators making big impacts:regulation of neural stem cells by small non-coding RNAs
Author(s): Zhong Liu, Rui Zhao
Pages: 397-398
Year: 2017 Issue: 3
Journal: Neural Regeneration Research
Abstract: Neurodegeneration and traumatic brain injuries are leading caus-es of disability and present an enormous disease burden both in terms of patient suffering and healthcare cost. Treatment of brain lesions remains as a major challenge in medicine largely because of the limited regenerative capacity of the adult brain. Neural stem cells (NSCs), which are present in the embryonic nervous system and in specific regions of the adult brain, have the capacity for self-renewal by making identical daughter NSCs, and for differ-entiation into all neural cell types including neurons, astrocytes, and oligodendrocytes, therefore represent a promising therapeu-tic cellular source to treat brain lesions (Gage and Temple, 2013). However, NSCs are susceptible to genotoxic insults because of their proliferative nature, which could lead to unregulated NSC proliferation and brain tumors (Vescovi et al., 2006).
Pages: 397-398
Year: 2017 Issue: 3
Journal: Neural Regeneration Research
Abstract: Neurodegeneration and traumatic brain injuries are leading caus-es of disability and present an enormous disease burden both in terms of patient suffering and healthcare cost. Treatment of brain lesions remains as a major challenge in medicine largely because of the limited regenerative capacity of the adult brain. Neural stem cells (NSCs), which are present in the embryonic nervous system and in specific regions of the adult brain, have the capacity for self-renewal by making identical daughter NSCs, and for differ-entiation into all neural cell types including neurons, astrocytes, and oligodendrocytes, therefore represent a promising therapeu-tic cellular source to treat brain lesions (Gage and Temple, 2013). However, NSCs are susceptible to genotoxic insults because of their proliferative nature, which could lead to unregulated NSC proliferation and brain tumors (Vescovi et al., 2006).
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