High Density Lipoprotein Antioxidant Capacity and Subtype Distribution and Analysis of Paraoxonase-1 Activity in Patients with Systemic Lupus Erythematosus
Author(s): Gao Tianyuan, Tian Qiong, Liu Wenli, Mu Xin, Zhang Jian
Pages: 16-19
Year: 2017 Issue: 1
Journal: Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine
Keyword: Systemic lupus erythematosus; High density lipoprotein antioxidant capacity; High density lipoprotein subpopulation; High density lipoprotein subfractions; Paraoxonase-1;
Abstract: Objective In order to investigate the relationship between systemic lupus erythematosus (SLE) and high-density lipoprotein (HDL) antioxidant capacity,HDL subfractions,paraoxonase-1 (PON1) activity.Methods Several factors,including ESR,ApoA1,HDL-C,IL-6,MCP-1 and SAA were determined by normal methods in 50 SLE patients and 50 healthy controls.HDL antioxidant capacity was determined spectrophotometrical method.Lipoprint system was used for HDL subfraction analysis.PON1 paraoxonase activity and arylesterase activity analyzed using paraoxon and phenylacetate as the substrate.Results Compared with healthy controls,HDL-C (P=0.012) and ApoA1 (P=0.003) concentrations decreased significantly in SLE subjects.Total HDL antioxidant capacity (P=0.002),HDL subfractions (P＜0.05) and PON1 arylesterase activity (P=0.001) were significantly reduced in SLE patients.The levels of hsCRP,ESR,IL-6,MCP-1 and SAA were significantly elevated in SLE patients (P＜0.05).HDL-C and total HDL antioxidant capacity correlated positively with PON 1 paraoxonase activity and arylesterase activity,and negatively with hsCRP,ESR,IL-6,MCP-1 and SAA,respectively.PON1 aryl esterase activity and ESR were independent predictors of total HDL antioxidant capacity.Conclusion Reduction of HDL antioxidant and PON1 activity,alteration of subfractions distribution and inflammation may contribute to the increased atherosclerosis risk of SLE patients.
Pages: 16-19
Year: 2017 Issue: 1
Journal: Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine
Keyword: Systemic lupus erythematosus; High density lipoprotein antioxidant capacity; High density lipoprotein subpopulation; High density lipoprotein subfractions; Paraoxonase-1;
Abstract: Objective In order to investigate the relationship between systemic lupus erythematosus (SLE) and high-density lipoprotein (HDL) antioxidant capacity,HDL subfractions,paraoxonase-1 (PON1) activity.Methods Several factors,including ESR,ApoA1,HDL-C,IL-6,MCP-1 and SAA were determined by normal methods in 50 SLE patients and 50 healthy controls.HDL antioxidant capacity was determined spectrophotometrical method.Lipoprint system was used for HDL subfraction analysis.PON1 paraoxonase activity and arylesterase activity analyzed using paraoxon and phenylacetate as the substrate.Results Compared with healthy controls,HDL-C (P=0.012) and ApoA1 (P=0.003) concentrations decreased significantly in SLE subjects.Total HDL antioxidant capacity (P=0.002),HDL subfractions (P＜0.05) and PON1 arylesterase activity (P=0.001) were significantly reduced in SLE patients.The levels of hsCRP,ESR,IL-6,MCP-1 and SAA were significantly elevated in SLE patients (P＜0.05).HDL-C and total HDL antioxidant capacity correlated positively with PON 1 paraoxonase activity and arylesterase activity,and negatively with hsCRP,ESR,IL-6,MCP-1 and SAA,respectively.PON1 aryl esterase activity and ESR were independent predictors of total HDL antioxidant capacity.Conclusion Reduction of HDL antioxidant and PON1 activity,alteration of subfractions distribution and inflammation may contribute to the increased atherosclerosis risk of SLE patients.
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