That's really where Deadpool vs. Punisher succeeds. It doesn't take much effort to concoct a scenario where Wade and Frank would conceivably cross paths. The trick is to build a conflict where both characters have a personal investment. Van Lente and Perez do that with the introduction of "The Bank," a crooked money launderer who also happens to be one of the few true friends Wade has in the world. The Bank is more than just another faceless goon for the Punisher to blast, and as such there's no clear divide between good and evil in the Punisher/Deadpool feud.
Perez is able to deftly toe the line between the grim, blood-soaked style of Punisher's world and Deadpool's brand of zany comedy. His crisp line-work and cleanly defined facial expressions also go a long way towards mining the most comedy out of Van Lente's script. Perez's figure work can be a little stiff at times, but otherwise he brings plenty of energy to the page. Various other little visual and lettering flourishes help make the most of this violent clash between two polar opposite characters.