[Purpose] Occlusion training with low-intensity resistance exercises and blood flow restriction increases muscle cross-sectional area and strength. This form of training is used in rehabilitation; therefore, the aim of this study was to examine the effect of one occlusion training session on the cardiovascular response to bouts of exercise. [Subjects and Methods] Two groups took part: a control group without blood flow restriction and an experimental group with blood flow restriction. A single training session was used with the exercise intensity set at 40% of the one repetition maximum. Maximum voluntary contraction, arterial blood pressure, and electrocardiogram measurements were performed. [Results] Heart rate was slightly higher in the control group. The performed training had no effect on diastolic blood pressure in either group, however, a tendency for a small systolic blood pressure increase was observed during the session in the experimental group. JT interval changes did not reveal significant differences between groups. There were no significant changes in ST-segment depression during the exercise or at rest. A lower tendency for JT/RR increases was observed during the repeated exercise tasks with partial blood flow restriction. [Conclusion] Low intensity exercises carried out with a partial blood flow restriction do not result in significant overload of cardiac function.