Heparan sulfate proteoglycans and heparanases in Alzheimer's disease:current outlook and potential therapeutic targets
Pages: 914-915
Year: 2017 Issue: 6
Journal: Neural Regeneration Research
Abstract: Relevance of Alzheimer's disease (AD): AD is one of the great-est health-care challenges of the 21st century. It is known to be the most common neurodegenerative disease and, in the United States, the sixth most common cause of death. It is estimated that 40 million people in the world suffer from dementia, most-ly people older than 60 years. With the increase of the survival, this incidence is projected to be doubled every 20 years (Schel-tens et al., 2016). Between 1997 and 2050, the elderly popula-tion, defined as subjects 65 years of age and older, will increase from 63 to 137 million in the Americas, from 18 to 38 million in Africa, from 113 to 170 million in Europe, and from 172 to 435 million in Asia, so we are looking straight to a public health problem.
Year: 2017 Issue: 6
Journal: Neural Regeneration Research
Abstract: Relevance of Alzheimer's disease (AD): AD is one of the great-est health-care challenges of the 21st century. It is known to be the most common neurodegenerative disease and, in the United States, the sixth most common cause of death. It is estimated that 40 million people in the world suffer from dementia, most-ly people older than 60 years. With the increase of the survival, this incidence is projected to be doubled every 20 years (Schel-tens et al., 2016). Between 1997 and 2050, the elderly popula-tion, defined as subjects 65 years of age and older, will increase from 63 to 137 million in the Americas, from 18 to 38 million in Africa, from 113 to 170 million in Europe, and from 172 to 435 million in Asia, so we are looking straight to a public health problem.
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